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Expression of inflammatory markers in a genetic rodent model of depression
(Elsevier, 2015)
The complex bidirectional communication between the central nervous system and the peripheral immune system is of possible relevance for both normal brain functions and the development of psychiatric disorders. The aim of ...
GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment
(Cambridge Univ Press, 2015)
Objective: Glucagon-like peptide 1 (GLP-1) receptor agonists are a new
group of antidiabetic medications quickly gaining popularity. We aimed to
examine behavioural and neuroendocrine changes following chronic
treatment ...
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
(Springer, 2016)
Rationale
The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ...
A gene-environment study of cytoglobin in the human and rat hippocampus
(PLoS, 2013)
Background: Cytoglobin (Cygb) was discovered a decade ago as the fourth vertebrate heme-globin. The function of Cygb is
still unknown, but accumulating evidence from in vitro studies point to a putative role in scavenging ...
A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses
(Wiley, 2014)
Communication between neurons is mediated by the
release of neurotransmitter-containing vesicles from
presynaptic terminals. Quantitative characterization of
synaptic vesicles can be highly valuable for understanding
...
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
(Wiley, 2013)
Depressive disorders and the treatment thereof have been associated
with a number of neuroplastic events, such as neurogenesis and synaptic remodeling
in discrete areas of the brain. The associations of these events in ...
The Flinders sensitive line rat model of depression: 25 years and still producing
(ASPET, 2013)
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats was completed before that seminal ...
MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro
(Oxford Univ Press, 2016)
Background:
MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the ...
The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
(Elsevier, 2020)
We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated ...
A preclinical study of casein glycomacropeptide as a dietary intervention for acute mania
(Oxford Univ Press, 2018)
Background
Casein glycomacropeptide is a peptide that lacks phenylalanine, tyrosine, and tryptophan. This profile may enable it to deplete phenylalanine, tyrosine, and tryptophan, and subsequently the synthesis of dopamine ...