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The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
(MDPI, 2017)
l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ...
Adherence challenges encountered in an intervention programme to combat chronic non-communicable diseases in an urban black community, Cape Town
(AOSIS, 2017)
Background: Chronic non-communicable diseases (CNCD) have become the greatest contributor to the mortality rate worldwide. Despite attempts by Governments and various non-governmental organisations to prevent and control ...
An elderly, urban population: their experiences and expectations of pharmaceutical services in community pharmacies
(AOSIS, 2017)
Objective: The aim of this study was to determine the pharmaceutical services experiences of an elderly, urban population in relation to their expectations in community pharmacy.
Design: and setting: The study was a ...
A conceptual framework to facilitate clinical judgement in nursing: a methodological perspective
(AOSIS, 2017)
The South African health care and education systems are challenged to provide independent,
critical thinking nurses who can cope with diversity in a creative way and define their
role in a complex, uncertain, rapidly ...
Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015
(Elsevier, 2017)
Background
The scale-up of tobacco control, especially after the adoption of the Framework Convention for Tobacco Control, is a major public health success story. Nonetheless, smoking remains a leading risk for early death ...
S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression
(Oxford Univ Press, 2017)
Background:
The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In ...
Community caregivers' perspectives of community well-being in a mining community
(AOSIS, 2017)
Mining communities throughout the Southern African Development Community are faced with numerous challenges impacting on their wellbeing. As part of an integrative multidisciplinary research project, this study sought to ...
Consumer decision-making and psycho-social well-being as complementary perspectives: a narrative review
(SAAFECS, 2017)
Globalisation contributes to an abundance of marketing, which stimulates unneeded and unplanned purchases. Research indicates that although consumers differ in terms of their purchasing styles and their consideration of ...
Addressing low-literacy in the South African clothing retail environment
(SAAFECS, 2017)
Low-literate consumers display distinctive behaviour in the marketplace, which entails concrete thinking (for example, the use of single pieces of information) and pictographic thinking (for example, the use of information ...
Conceptualising a proposed support strategy for sexually abused boys in middle childhood
(Univ Stellenbosch, 2017)
Male child sexual abuse in middle childhood has serious effects with the increased risk of development of various mental illnesses and disorders, as well as extreme forms of emotional and behavioural problems. This study ...