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Mortality and morbidity in relation to changes in albuminuria, glucose status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies
(Springer Verlag (Germany), 2014)
Aims/hypothesis Urinary albumin excretion is a strong predictor of cardiovascular disease. It is uncertain whether improvement from microalbuminuria or deterioration from normoalbuminuria over time in patients with differing ...
Using an innovative mixed method methodology to investigate the appropriateness of a quantitative instrument in an African context: antiretroviral treatment and quality of life
(Taylor & Francis, 2014)
The relationship between quality of life (QoL) and antiretroviral treatment (ART) has mainly been studied using quantitative scales often not appropriate for use in other contexts and without taking peoples' lived experiences ...
Validation of the children's leisure activities study survey questionnaire for 12-year old South African children
(LAM Publications; AJOL; Sabinet, 2014)
This study evaluated the reliability and construct validity of a modified Children's Leisure Activities Study Survey (CLASS) questionnaire for 12-year old South African children. Test-retest reliability of the questionnaire ...
A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses
(Wiley, 2014)
Communication between neurons is mediated by the
release of neurotransmitter-containing vesicles from
presynaptic terminals. Quantitative characterization of
synaptic vesicles can be highly valuable for understanding
...
More good news about polymeric plant- and algae-derived biomaterials in drug delivery systems
(Bentham Science, 2014)
Natural polymers are continuously investigated for use in pharmaceutical and tissue engineering applications due to the renewability of their supply. Besides the conventional use of natural materials in dosage form design ...
Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents
(Elsevier, 2014)
The aim of this study was to design drug-like molecules with multiple neuroprotective mechanisms
which would ultimately inhibit N-methyl-D-aspartate (NMDA) receptors, block L-type voltage gated
calcium channels (VGCC) ...
Association between insulin-like growth factor-1, measures of overnutrition and undernutrition and insulin resistance in black adolescents living in the north-west province, South Africa
(Wiley, 2014)
Objective
To determine if insulin-like growth factor-1 (IGF-1) is a significant predictor of body fat percentage (%BF), lean body mass, and insulin resistance (IR) in black adolescents presenting with overnutrition and ...
Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives
(Elsevier, 2014)
Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and ...
Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides
(Elsevier, 2014)
A series of 4-aminoquinolinyl-chalcone amides 11–19 were synthesized through condensation of carboxylic
acid-functionalized chalcone with aminoquinolines, using 1,10-carbonyldiimidazole as coupling
agent. These compounds ...
Impact of traditional African medicine on drug metabolism and transport
(Taylor & Francis, 2014)
Introduction: Africa is a continent of rich plant biodiversity with many
indigenous plants having a long history of being used for medicinal purposes.
A considerable number of patients consult traditional healers in ...