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Adiposity and physical activity are related to heart rate variability: the African-PREDICT study
(Wiley, 2020)
Background
Physical inactivity contributes significantly to the development of obesity‐related cardiovascular disease. Adiposity may lead to reduced heart rate variability (HRV), whereas increased physical activity (PA) ...
Retinal vessel caliber and caliber responses in true normotensive black and white adults: the African-PREDICT study
(Elsevier, 2020)
Purpose
Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis ...
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
(Springer, 2020)
Nitric oxide plays an important role in maintaining endothelial function, while increased oxidative stress may lead to nitric oxide inactivation and cardiovascular disease. If nitric oxide biosynthesis/bioavailability is ...
Distinct inflammatory mediator patterns in young black and white adults: the African-predict study
(Elsevier, 2020)
Objective
Inflammatory mediators have been implicated in the early stages of cardiovascular disease development, including hypertension. Since global reports reflect a higher hypertension prevalence in black than white ...
Retinal vasculature reactivity during flicker light provocation, cardiac stress and stroke risk in Africans: the SABPA study
(Springer, 2019)
Structural and functional similarities exist between the retinal, cerebral and, as previously suggested, the coronary microvasculature. Retinal microvascular structure and functionality (in response to flicker-light-indu ...
Defensive coping and subclinical vascular disease risk – associations with autonomic exhaustion in Africans and caucasians: the SABPA study
(Elsevier, 2012)
Objective
The defensive active coping response is a recognised cardiovascular risk factor in Africans, especially in men. It is uncertain whether autonomic dysfunction might be the underlying cause. We therefore investigated ...
Ethnicity-specific differences in L-arginine status in South African men
(Nature Publishing Group, 2012)
The aetiology for an increasing incidence of hypertensive cardiovascular disease amongst Africans in southern Africa is unclear. Hypertension may be induced by inadequate release of L-arginine-derived nitric oxide impairing ...
Left ventricular mass independently associates with masked hypertension in young healthy adults: the African-PREDICT study
(Wolters Kluwer, 2018)
Objective: Masked hypertension is reportedly common in young adults. However, it is unknown if these masked hypertensive individuals already present with organ damage. We determined whether a relationship exists between ...
Exploring the link between serum peroxides and angiogenesis in a bi-ethnic population from South Africa: the SAfrEIC study
(Elsevier, 2013)
Background:
Reactive oxygen species (ROS) play a fundamental role in angiogenesis, and in turn, angiogenic growth factors also affect ROS. Angiogenesis and ROS are intricately involved in vascular deterioration. Since ...
Leukocyte telomere length and hemostatic factors in a South African cohort: the SABPA study
(Wiley, 2014)
Background
Incident atherothrombotic disease is predicted by leukocyte telomere length, a marker of biological age, and hemostatic factor levels, indicating a hypercoagulable state. We hypothesized that shorter telomeres ...