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Hexacyclododecylamines with Sigma-1 receptor affinity and calcium channel modulating ability
(Bentham Open, 2019)
Introduction:
Recent research points to the Sigma Receptor (σR) as a possible neuromodulatory system with multi-functional action and σ1Rs have been suggested as a drug target for a number of CNS conditions. Hexacyclodo ...
Determinants of undernutrition prevalence in children aged 0–59 months in sub-Saharan Africa between 2000 and 2015. A report from the World Bank database
(Cambridge Univ Press, 2019)
Objective
To determine undernutrition prevalence in 0–59-month-old children and its determinants during the period 2000–2015 in sub-Saharan Africa.
Design
Ecological study of time series prevalence of undernutrition ...
Heart rate variability and the dynamic nature of the retinal microvasculature: providing insight into the brain-retina-heart link: the SABPA study
(Karger, 2019)
Controversy exists regarding the contribution of
the autonomic nervous system (ANS) to the retinal microvasculature’s autoregulatory capacities. It was demonstrated that mean
retinal vessel responses to systemic sympathetic ...
Experiences of student nurses regarding the bursary system in KwaZulu-Natal province, South Africa
(AOSIS, 2019)
Background: During 2010, the South African nursing education system was restructured, changing student nurses from having supernumerary status to being bursary holders. Changes with the introduction of this new bursary ...
High sedentary behaviour and low physical activity are associated with anxiety and depression in Myanmar and Vietnam
(MDPI, 2019)
The study aimed to estimate independent and combined associations of sedentary behaviour and physical activity with anxiety and depression among chronic disease patients in Myanmar and Vietnam. The cross-sectional sample ...
Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: the SABPA study
(Karger, 2019)
Assessment of the retinal vessels’ structure and
function provides an automated and objective approach to noninvasively assess the condition of the cerebral microvasculature
and indicates susceptibility for stroke. ...
The oxidative stress profile and its relation to vascular function in a bi-ethnic cohort: the SABPA study
(Karger, 2019)
Oxidative stress and inflammation
has been implicated in arterial stiffness, and hypertension development. Oxidative stress may interfere with normal vascular function by inactivation of NO and/or the production of ...
Retinal vessel caliber and vessel reaction to light flicker in true normotensive young healthy black and white adults: the African-PREDICT study
(Karger, 2019)
A detrimental shift in cardiovascular disease risk
factors and a higher mortality level are reported in some black
populations. The retinal microvasculature provides insight into
the pathogenesis of systemic vascular ...
Considerations for an in vitro, cell-based testing platform for detection of adverse drug-induced inotropic effects in early drug development. Part 1: General considerations for development of novel testing platforms
(Frontiers Media, 2019)
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted ...