Search
Now showing items 21-30 of 176
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study
(Elsevier, 2016)
Background
Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear.
Objectives ...
Evaluation of isolated fractions of aloe vera gel materials on indinavir pharmacokinetics: in vitro and in vivo studies
(Bentham Science, 2016)
Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed medicines. A. vera gel has shown the ability to modulate drug absorption ...
Obsessive-compulsive disorder: insights from animal models
(Elsevier, 2016)
Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ...
The long-term effects of methamphetamine exposure during pre-adolescence on depressive-like behaviour in a genetic animal model of depression
(Springer, 2016)
Methamphetamine (METH) is a psychostimulant and drug of abuse, commonly used early in life, including in childhood and adolescence. Adverse effects include psychosis, anxiety and mood disorders, as well as increased risk ...
Perceptions of pharmacists towards the importance of work-life balance: a descriptive cross-sectional study from Pakistan
(College of Pharmacists of Buenos Aires Province, Argentina, 2016)
The present study was designed to evaluate the pharmacist’s perceptions towards the impor-
tance of different factors responsible for work-life in Pakistan. A descriptive cross-sectional study design
was used. A questionnaire ...
Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound
(Wiley, 2016)
This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the ...
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
(Springer, 2016)
Rationale
The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ...
Essential fatty acids as transdermal penetration enhancers
(Elsevier, 2016)
The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ...
In vitro skin permeation of artemisone and its nano-vesicular formulations
(Elsevier, 2016)
The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid
lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such
formulations ...
Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P
(Govi-Verlag, 2016)
Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ...