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Selenium and large artery structure and function: a 10-year prospective study
(Springer, 2019)
Purpose
Despite selenium’s beneficial effects in counteracting oxidative stress, inflammation, and vascular endothelial dysfunction, controversial results exist regarding the long-term associations between selenium and ...
Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase
(Springer, 2019)
Based on reports that chromone compounds are good potency inhibitors of monoamine oxidase (MAO), the present study evaluates the effect of substitution with flexible side chains on the 3 position on MAO inhibition potency. ...
The evaluation of metal co-ordinating bis-thiosemicarbazones as potential anti-malarial agents
(Bentham Science, 2019)
Background:
The emergence of resistance to the artemisinins which are the current mainstays for antimalarial chemotheraphy has created an environment where the development of new drugs acting in a mechanistally discrete ...
An HPLC-DAD validated method for the detection and quantification of cortisol, corticosterone and melatonin in plasma samples of two different animal species
(Avoxa, 2019)
The monitoring of endogenous hormone plasma levels could be valuable in biomedical, veterinary and pharmaceutical research. A specific high performance liquid chromatography method with diode array detection, for the assay ...
Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli
(Elsevier, 2019)
Depression is a debilitating mental illness and two thirds of patients respond insufficiently to conventional antidepressants. Electroconvulsive therapy (ECT) remains the most effective treatment to alleviate drug-refractory ...
Animal models of major depressive disorder and the implications for drug discovery and development
(Taylor & Francis, 2019)
Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is ...
The behavioural self-regulation strategies of Indian South African university students: an exploratory study
(Taylor & Francis, 2019)
This study explored the race-related self-regulation strategies of eight Indian South African university students (females: n = 4) attending a historically white university. Interactive qualitative analysis of their ...
Guideline for conducting critical reviews in psychology research
(Taylor & Francis, 2019)
While numerous guidelines for conducting the various types of reviews are available within literature, there is limited information to inform researchers on how to conduct a critical review. We searched the following data ...
Exploring a gene-x-environment model of treatment resistant depression: behavioural studies and response to fluoxetine treatment
(Elsevier, 2019)
Background: Major depression with psychotic features presents with severe depressed mood and psychosis in the form of nihilistic-type delusions and hallucinations, and is known to be resistant to antidepressant monotherapy ...
Monoamine oxidase inhibition by selected dye compounds
(Wiley, 2019)
Monoamine oxidase (MAO) is an important drug target as the MAO isoforms play key roles in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as in neuropsychiatric diseases such as ...