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MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro
(Oxford Univ Press, 2016)
Background:
MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the ...
Methylene homologues of artemisone: an unexpected structure-activity relationship and a possible implication for the design of C10-substituted artemisinins
(Wiley, 2016)
We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides ...
Discovery of 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine derivatives as novel adenosine A1 and A2A receptor antagonists
(Elsevier, 2016)
Based on a previous report that a series of 8-(phenoxymethyl)-xanthines may be promising leads for the design of A1 adenosine receptor antagonists, selected novel and known 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine ...
Reference gene selection for in vitro cell-free DNA analysis and gene expression profiling
(Elsevier, 2016)
Objectives: (i) To optimize cell-free DNA (cfDNA) and mRNA quantification using eight housekeeping genes
(HKGs), (ii) to determine if there is a difference in the occurrence of HKGs in the cfDNA andmRNA of normal cells
and ...
Biomechanical benefits of symmetrical strengthening of hip extensors among athletes: a review
(LAM Publications Limited, 2016)
There is abundant literature encouraging athletes to engage in concurrent strength training. However, little emphasis is placed on the value of biomechanics with regard to symmetrical strengthening of force-couple ...
What is the status of soccer injuries among female players? A systematic review
(LAM Publications Limited, 2016)
This review provides an overview of the literature pertaining to female soccer injuries from
2007-2016. The dissemination of female soccer injury surveillances in Africa, America and
Europe ...
Advances in GBA-associated Parkinson's disease: pathology, presentation and therapies
(Elsevier, 2016)
GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic GBA mutations cause Gaucher disease, both mono- and ...
The nature of community health care centre practice environments in a province in South Africa
(Unisa Press, 2016)
The practice environment plays an important role in nursing. Currently, limited information seems to exist on the nature of practice environments within the primary health care (PHC) context of the public health care sector ...
Physical stability and clinical efficacy of Crocodylus niloticus oil lotion
(Elsevier, 2016)
The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus oil lotion was determined. The lotion was stored at controlled conditions over six months during which ...
Exploring adolescents' participation in decision-making in the home schooling context
(Stellenbosch University, 2016)
The purpose of this study was to explore the participation of adolescents in decision-making in the home school context. The sample consisted of 21 participants from 8 families in the Western Cape. Data collection was done ...