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Translational medicine strategies in PTSD drug development
(Elsevier, 2019)
Once considered a normal response to an abnormal traumatic event, posttraumatic stress disorder (PTSD) has been reconceptualized in terms of unusual persistence of fear-conditioned responses. Selective serotonin reuptake ...
A pilot study: use of the adult adhd-self report scale in a south african patient population
(Springer, 2019)
Introduction: Attention-Deficit/Hyperactivity Disorder (ADHD) is a
neurodevelopmental disorder which typically presents in childhood.
This diagnosis may often be overlooked in adulthood, particularly in
psychiatric ...
An update on derivatisation and repurposing of clinical nitrofuran drugs
(Elsevier, 2019)
5-nitrofurans (NFs) have been in clinical use for over 60 years. These affordable drugs are used for the treatment of a broad spectrum of diseases ranging from urinary tract infections to cancer. The anti-pathogenic effect ...
Determination of lovastatin, mevastatin, rosuvastatin and simvastatin with HPLC by means of gradient elution
(Avoxa, 2019)
A novel HPLC method with UV detection was developed and validated in skin penetration (in vitro) studies to identify and quantify lovastatin, mevastatin, rosuvastatin and simvastatin. A Venusil XBP C18 (2), 150 x 4.6 mm, ...
Synthesis and antimycobacterial activity of disubstituted benzyltriazoles
(Springer, 2019)
The increasing prevalence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the ...
Comparison of DOTA and NODAGA as chelates for 68Ga-labelled CDP1 as novel infection PET imaging agents
(Springer, 2019)
The cathelicidin-derived peptide (CDP1) is a human antimicrobial peptide that preferentially targets bacterial membranes in response to infection. CDP1 was functionalised with NODAGA and DOTA for complexation with gallium-68 ...
In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis
(ASM, 2019)
Mycobacterium tuberculosis, the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such ...
Monoamine oxidase inhibition by Kavalactones from Kava (Piper Methysticum)
(Thieme, 2019)
Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and neurodegenerative disorders. This study examined the MAO inhibition ...
Adult attachment theory and Rorschach Inkblot Method: a systematic literature review
(Taylor & Francis, 2019)
This critical appraisal and synthesis review explores the literature on the evidence of Rorschach Inkblot Method variables as measures of the attachment theory. We searched for publications making use of EBSCO Discovery ...
Aloe vera gel and whole leaf extract: functional and versatile excipients for drug delivery?
(Taylor & Francis, 2019)
Aloe vera (L.) Burm.f. (Aloe barbadensis Miller) is a perennial xerophyte plant that has many medicinal applications. A. vera leaves contain water storage tissue, which is fundamentally made up of a viscous mucilage contained ...