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Prescribing patterns of non-steroidal anti-inflammatory drugs in chronic kidney disease patients in the South African private sector
(Springer, 2016)
Background Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used pharmaceutical agents worldwide. NSAIDs are considered nephrotoxic and should therefore be used with caution or be avoided completely ...
Synthesis and in vitro biological activities of ferrocenyl-chalcone amides
(Springer, 2016)
A series of aminoferrocenyl–chalcone amides 11–19 were synthesized through condensation of a carboxylic acid-functionalized chalcone 10 with ferrocenylamines, using 1,1′-carbonyldiimidazole as the coupling agent. The ...
Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities
(Elsevier, 2016)
As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ...
Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin
(Elsevier, 2016)
In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and ...
Investigation of the coexistence of CKD and non-communicable chronic diseases in a PBM company in South Africa
(Taylor & Francis, 2016)
Background: Chronic kidney disease (CKD) is a public health problem, with increasing global prevalence. Several factors could influence the prognosis of CKD, including comorbid chronic conditions. This study investigated ...
Medicine possession ratio as proxy for adherence to antiepileptic drugs: prevalence, associations, and cost implications
(Dovepress, 2016)
Objective: To determine the adherence status to antiepileptic drugs (AEDs) among epilepsy patients; to observe the association between adherence status and age, sex, active ingredient prescribed, treatment period, and ...
Inappropriate medicine prescribing in older South Africans: a cross-sectional analysis of medicine claims data
(Health & Medical Publishing Group, 2016)
Background. Prescribing for older patients is a well-recognised problem, and inappropriate items are prescribed frequently. Several tools
and criteria are available to promote rational prescribing in older patients.
Objective. ...
Cell based assays for anti-Plasmodium activity evaluation
(Elsevier, 2016)
Malaria remains one of the most common and deadly infectious diseases worldwide. The severity of this global public health challenge is reflected by the approximately 198 million people, who were reportedly infected in ...
Non-prescription sale and dispensing of antibiotics in community pharmacies in Zambia
(Taylor & Francis, 2016)
Background: In Zambia, antibiotics are categorized as prescription-only medicines. Antibiotics dispensed without a prescription pose a public health threat, which is a concern. Consequently, the aim is to ascertain the ...
Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
(Elsevier, 2016)
Background
Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of
health across geographies and time that can inform assessments of epidemiological patterns ...