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Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression
(Wiley, 2016)
Glutamatergic abnormalities have recently been implicated in the pathophysiology of depression, and the ionotropic glutamate receptors in particular have been suggested as possible underlying molecular determinants. The ...
A novel RP-HPLC method for the detection and quantification of clarithromycin or spiramycin in bulk drug samples and dosage forms
(Innovare Academic Sciences, 2016)
Objective: This study was aimed at developing an HPLC method that would be suitable and sufficiently robust to analyze clarithromycin or spiramycin from bulk materials, amorphous solid dispersions as well as when included ...
Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
(Hindawi Publishing Corporation, 2016)
Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT). The delta and epsilon classes of insect GSTs ...
Students’ perception of the perceived availability and diversion of methylphenidate in a South African tertiary academic institution
(SAPJ, 2016)
Aims: To determine where residence students from a South African tertiary institution get methylphenidate for both appropriate and non-medical use, where they think they could get it and how easy they think it is to ...
A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles
(Springer, 2016)
The discovery of quantitative and qualitative
differences of the circulating DNA (cirDNA) between
healthy and diseased individuals inclined researchers to
investigate these molecules as potential biomarkers for
non-invasive ...
Dietary sodium and cardiovascular disease risk
(Massachusetts Medical Society, 2016)
Synthesis and biological evaluation of pentacycloundecylamines and triquinylamines as voltage-gated calcium channel blockers
(Wiley, 2016)
Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as ...
Maximum potential cost-savings attributable to generic substitution of antipsychotics 2008 to 2013
(Elsevier, 2016)
Background
Schizophrenia is a costly illness to treat, especially during a time of escalating medicine inflation costs, putting a large economic strain on patients, their families and the community. Treatment, however, ...
The effectiveness of training and retraining at various frequencies on the aerobic capacity and intrinsic cardiovascular dynamics (systolic time intervals) in south african employees
(LAM Publications Ltd, 2016)
Cardiovascular disease (CVD) remains a serious health threat in most countries globally, placing
a severe burden on the workforce in the corporate environment. Physical activity intervention has
already been indicated ...
Relationship between body image and socio-economic status in South African adolescents: PAHL-study
(Stellenbosch Univ, 2016)
The aim of this study was to determine the body image (BI) and its relationship with socio-economic status (SES) among adolescents. The 15-year-old adolescents (N=287), consisting of 111 boys and 176 girls, were grouped ...