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Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)
Depressive disorders represent a significant health concern as they are associated with high social and
physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective
treatment ...
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)
Depressive disorders represent a significant health concern as they are associated with high social and
physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective
treatment ...
Isolation-induced behavioural changes in a genetic animal model of depression
(Elsevier, 2012)
Depression is a heterogeneous disorder displaying a range of symptoms including feelings of despair and social withdrawal. Social isolation may complicate the progression of depression and have effects on both behaviour ...
Quantitative hippocampal structural changes following elctroconvulsive seizure treatment in a rat model of depression
(Wiley, 2012)
Objective: The pathophysiology of depression and the effects of antidepressant
treatment are hypothesized to be related to hippocampal structural
changes. This study aims to investigate the effect of electroconvulsive ...
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
(Elsevier, 2012)
Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result
possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine
oxidase A ...
The schizophrenia and bipolar disorder associated BRD1 gene is regulated upon chronic restraint stress
(Elsevier, 2012)
Recent genetic evidence has implicated the bromodomain containing 1 gene (BRD1) with brain development and susceptibility to Schizophrenia and Bipolar Disorder. The BRD1 protein, which is essential for acetylation of histone ...
Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats
(Springer, 2012)
There are conflicting results from behavioural studies regarding whether the activation or inhibition of the cGMP-nitric oxide (NO) pathway induces anxiolytic-like behaviour. Sildenafil, an inhibitor of cGMP-selective ...