Search
Now showing items 1-2 of 2
S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression
(Oxford Univ Press, 2017)
Background:
The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In ...
The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex
(Elsevier, 2017)
It is well established that stress plays a major role in the pathogenesis of neuropsychiatric diseases. Stress-induced alteration of synaptic plasticity has been hypothesized to underlie the morphological changes observed ...