Now showing items 1-5 of 5
C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study
Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ...
Monitoring the South African population’s salt intake: spot urine v. 24 h urine
(Cambridge Univ Press, 2018)
Objective The present study set out to determine whether morning spot urine samples can be used to monitor Na (and K) intake levels in South Africa, instead of the ‘gold standard’ 24 h urine sample. Design Participants ...
Chronic depression symptoms desensitize renin activity to protect against volume-loading hypertension in Blacks: the SABPA study
Background Low-renin levels in Blacks have been associated with volume-loading hypertension (HT). Depression symptoms, frequently co-occurring with vascular dysregulation, might reflect a disturbed renin-angiotensin-ald ...
Chronic disease list conditions in patients with rheumatoid arthritis in the private healthcare sector of South Africa
Introduction Little is known about the burden of rheumatoid arthritis (RA) in South Africa. The aim of this study was to establish the prevalence of RA and coexisting chronic disease list (CDL) conditions in the private ...
Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study
(Taylor & Francis, 2018)
Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It ...