Search
Now showing items 1-9 of 9
Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat
(Springer, 2018)
There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and ...
Methylene blue analogues with marginal monoamine oxidase inhibition retain antidepressant-like activity
(ACS, 2018)
Methylene blue (MB) possesses diverse medical applications. Among these, MB presents with antidepressant-like effects in animals and has shown promise in clinical trials for the treatment of mood disorders. As an antidepressant, ...
Immediate and long-term antidepressive-like effects of pre-pubertal escitalopram and omega-3 supplementation combination in young adult stress-sensitive rats
(Elsevier, 2018)
Major depressive disorder (MDD) affects a significant number of children and adolescents, yet treatment options for this population remain very limited. Escitalopram (ESC) is one of only two antidepressants approved as ...
Ketamine and rapidly acting antidepressants: breaking the speed of sound or light?
(Sage, 2018)
There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key ...
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex
(Sage, 2018)
Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ...
Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges
(Springer, 2018)
Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding ...
Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs
(ASPET, 2018)
Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep disturbances, nervousness, anxiety, depression, ...
Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats
(Nature, 2018)
Efavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of
efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following
sub-acute exposure ...
Distinct intrinsic functional brain network abnormalities in methamphetamine‐dependent patients with and without a history of psychosis
(Wiley, 2018)
Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default ...