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Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)
Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ...
Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium
(Oxford Univ Press, 2015)
Background: Telomeres are protective DNA-protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Shortening of the blood leukocyte telomeres is associated with aging, several chronic ...
MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro
(Oxford Univ Press, 2016)
Background:
MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the ...
Prevalence of comorbidities in women with and without breast cancer in Soweto, South Africa: results from the SABC study
(HMPG, 2019)
Background. Comorbidities occurring concurrently in breast cancer patients can be burdensome, as they may negatively influence time and stage of presentation.
Objectives. To describe the comorbid health conditions among ...
An explorative study on the relationship between learning opportunities at school and at work and adolescents' mental health
(Ubiquity Press, 2020)
Based on the Job Demands-Resources model, this study examined the association of
learning opportunities of adolescents at school and work with their mental health,
operationalized in terms of life satisfaction and ...
Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression
(Cambridge Univ Press, 2019)
Objectives:
Treatment-resistance to antidepressants is a major problem in the pharmacotherapy of major depressive disorder (MDD). Unfortunately, only a few animal models are suitable for studying treatment-resistant ...
High sedentary behavior is associated with depression among rural South Africans
(MDPI, 2019)
The study aimed to investigate the association between sedentary behavior and depression among rural South Africans. Data were analyzed from the cross-sectional baseline survey of the “Health and Aging in Africa: A ...
Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
(ABP - Brazilian Psychiatric Association, 2019)
Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative
biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers.
Bipolar depression ...
The impact of a therapeutic exercise intervention on depression and body self-image in HIV-positive women in sub-Saharan Africa
(Dove Press, 2018)
Attitudes, responses, and reactions of HIV-positive women in three sub-Saharan African regions toward a therapeutic exercise intervention, aimed to determine the presence of depression and low body self-image, were captured. ...
Selectively bred rodents as models of depression and anxiety
(Springer, 2012)
Stress related diseases such as depression and anxiety have a high degree of co morbidity, and represent one of the greatest therapeutic challenges for the twenty-first century. The present chapter will summarize existing ...