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The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time
(Springer, 2011)
Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in ...
A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression
(Elsevier, 2011)
Major depressive disorder (MDD) and diabetes mellitus type II (T2DM) are two of the major health challenges of our time. It has been shown that MDD and T2DM are highly co-morbid, and recent work has proposed a bi-directional ...
Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function
(Elsevier, 2011)
Depressive symptoms have been consistently associated with sub-clinical atherosclerosis and future risk of coronary heart disease events. However, the pathways linking depression and coronary atherosclerosis are poorly ...
Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences
(Springer, 2011)
Ozone (O3) (CAS 10028-15-6) is a major air industrial pollutant and is well known for its very strong oxidative actions which affords the molecule its useful antimicrobial and deodorizing properties, but also its potential ...
An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats
(Elsevier, 2011)
Although it is well established that cyclic adenosine monophosphate (cAMP) signalling via cAMPdependent protein kinase (PKA)within neurons plays an important role in depression and antidepressant treatment, the importance ...
Dissociation between learning and memory impairment and other sickness behaviours during simulated Mycoplasma infection in rats
(Elsevier, 2011)
To investigate potential consequences for learning and memory, we have simulated the effects of Mycoplasma infection, in rats, by administering fibroblast-stimulating lipopepide-1 (FSL-1), a pyrogenic moiety of Mycoplasma ...
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
(Elsevier, 2011)
Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR ...
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
(Elsevier, 2011)
The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ...