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The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
(Springer, 2016)
Inadequate substrate availability and increased
nitric oxide synthase inhibitor levels attenuate nitric oxide
(NO) synthesis, whereas increased vascular oxidative
stress may lead to inactivation of NO. We compared
markers ...
Masked hypertension and its associated cardiovascular risk in young individuals: the African-PREDICT study
(Springer Nature, 2016)
Hypertension prevalence is increasing globally, yet little is known about the occurrence of masked hypertension (MHT) in young, sub-Saharan African adults, and how it relates to elevated cardiovascular risk. The African-PREDICT ...
Retinal vessel caliber and its relationship with nocturnal blood pressure dipping status: the SABPA study
(Springer Nature, 2016)
Adverse changes in retinal microvasculature caliber are associated with incident hypertension, coronary heart disease and stroke. The absence of a nocturnal dipping in arterial pressure may induce changes throughout the ...
Inter-arm blood pressure difference and its relationship with retinal microvascular calibres in young individuals: the African-PREDICT study
(Elsevier Science Inc, 2016)
Background
Bilateral systolic blood pressure (SBP) differences > 10 mmHg is a common finding in clinical practice. Such BP differences in older individuals are associated with peripheral vascular disease, linked to ...
Dependence of cardiac systolic function on elevated fatty acid availability in obese, insulin-resistant rats
(Elsevier, 2016)
Background
Clinical data advocating an adverse effect of obesity on left ventricular (LV) systolic function independent of comorbidities is controversial. We hypothesized that in obesity with prediabetic insulin resistance, ...
Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: a five-year prospective study
(Sage Publications Ltd, 2016)
Background:
Inconsistent findings are reported on whether insulin-like growth factor-1 (IGF-1) is protective or harmful
in predicting hypertension, carotid wall thickness and mortality. We determined the five-year ...
IGF-1 and NT-proBNP in a black and white population: the SABPA study
(Wiley, 2016)
Background
Black populations exhibit lower concentrations of the cardioprotective peptide, insulin-like growth factor-1 (IGF-1), and are more prone to develop hypertensive heart disease than whites. We therefore determined ...