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The evaluation of metal co-ordinating bis-thiosemicarbazones as potential anti-malarial agents
(Bentham Science, 2019)
Background: The emergence of resistance to the artemisinins which are the current mainstays for antimalarial chemotheraphy has created an environment where the development of new drugs acting in a mechanistally discrete ...
Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration
(Oxford Univ Press, 2019)
Objectives Drug resistance exists to all current and investigational antimalarial drug classes. Consequently, we have set out to develop chemically and mechanistically discrete antimalarials. Here we report on the development ...
Artemisia afra, a controversial herbal remedy or a treasure trove of new drugs?
Ethnoparmacological relevance Artemisia afra is one of the most widely used herbal remedies in South Africa. This highly aromatic shrub is used to treat various disorders including coughs, colds, influenza, and malaria. ...