Browsing Faculty of Natural and Agricultural Sciences by Author "ff6624bf-4e79-4323-97de-ecbe25723414"
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Accumulation patterns and risk assessment of metals and metalloid in muscle and offal of free-range chickens, cattle and goat in Benin City, Nigeria
Ogbomida, Emmanuel Temiotan; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Bortey-Sam, Nesta; Oroszlany, Balazs (Elsevier, 2018)The use of free range animals for monitoring environmental health offers opportunities to detect exposure and assess the toxicological effects of pollutants in terrestrial ecosystems. Potential human health risk of dietary ... -
Anthropogenic and naturally produced brominated phenols in pet blood and pet food in Japan
Mizukawa, Hazuki; Ikenaka, Yoshinori; Nomiyama, Kei; Yamamoto, Miyuki; Ishizuka, Mayumi (ACS, 2017)Present study determined concentrations and residue patterns of bromophenols (BPhs) in whole blood samples of pet cats and pet dogs collected from veterinary hospitals in Japan. BPhs concentrations were higher in cat blood ... -
Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa
Yohannes, Yared Beyene; Ikenaka, Yoshinori; Wepener, Victor; Smit, Nico J.; Ito, Gengo (Springer, 2017)Ethiopia and South Africa are among the few countries to still implement indoor residual spraying with dichloro-diphenyl-trichloroethane (DDT) for malaria vector control. In this study, we investigated the levels and ... -
Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana
Bortey-Sam, Nesta; Ikenaka, Yoshinori; Akoto, Osei; Nakayama, Shouta, M.M.; Asante, Kwadwo A. (Elsevier, 2018)Heavy metals and metalloids contamination in soils, water, food and livers of wild rats have been studied in Kumasi, Ghana and despite the estimated risks to residents, there is no epidemiological study to ascertain these ... -
Avian interspecific differences in VKOR activity and inhibition: insights from amino acid sequence and mRNA expression ratio of VKORC1 and VKORC1L1
Nakayama, Shouta M.M.; Ikenaka, Yoshinori; Morita, Ayuko; Kawai, Yusuke K.; Watanabe, Kensuke P. (Elsevier, 2020)Worldwide use of anticoagulant rodenticides (ARs) for rodents control has frequently led to secondary poisoning of non-target animals, especially raptors. In order to suggest some factors that may help considering the ... -
Characterization of function and genetic feature of UDP-glucuronosyltransferase in avian species
Kawai, Yusuke K.; Ikenaka, Yoshinori; Shinya, So; Saengtienchai, Aksorn; Kondo, Takamitsu (Elsevier, 2019)Birds are exposed to many xenobiotics during their lifetime. For accurate prediction of xenobiotic-induced toxic effects on avian species, it is necessary to understand metabolic capacities in a comprehensive range of bird ... -
Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species
Saengtienchai, Aksorn; Ikenaka, Yoshinori; Kawata, Minami; Kawai, Yusuke; Takeda, Kazuki (Elsevier, 2018)There have been many reports regarding toxic chemicals in birds. Chemicals are mainly metabolized in the liver through phase I oxidation by cytochrome P450 (CYP) and phase II conjugation by conjugated enzymes, such as ... -
Contamination by neonicotinoid insecticides and their metabolites in Sri Lankan black tea leaves and Japanese green tea leaves
Ikenaka, Yoshinori; Fujioka, Kazutoshi; Kawakami, Tomonori; Ichise, Takahiro; Bortey-Sam, Nesta (Elsevier, 2018)Tea is one of the world’s most popular beverages due to health promoting effects. Despite these, there have been concerns about the adverse effects of tea contamination by neonicotinoid insecticides. Only a handful of ... -
Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea
Ishii, Chihiro; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Mizukawa, Hazuki; Yohannes, Yared Beyene (Japanese Society of Veterinary Science, 2017)Seabirds are marine top predators and accumulate high levels of metals and metalloids in their tissues. Contamination by metals in the highly productive offshore region has become a matter of public concern. It is home ... -
DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia
Yohannes, Yared Beyene; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Mizukawa, Hazuki; Ishizuka, Mayumi (Elsevier, 2017)Despite the presence of a wide variety and number of birds, there is exceedingly little data on organochlorine pesticide (OCP) residues in birds inhabiting in Africa. In the present study, concentrations of dichlorodiphe ... -
Distribution and health risk assessment of organochlorine pesticides (OCPs) residue in edible cattle tissues from northeastern part of Egypt: high accumulation level of OCPs in tongue
Mahmoud, Abdallah Fikry A.; Ikenaka, Yoshinori; Yohannes, Yared B.; Darwish, Wageh S.; Eldaly, Elsaid A. (Elsevier, 2016)Food consumption is an important route of human exposure to organochlorine pesticides (OCPs). In order to assess the potential human health risks associated with OCPs, edible cattle tissues (liver, kidney and tongue) were ... -
Effects of PCB exposure on serum thyroid hormone levels in dogs and cats
Takaguchi, Kohki; Ikenaka, Yoshinori; Nishikawa, Hiroyuki; Mizukawa, Hazuki; Tanoue, Rumi (Elsevier, 2019)Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) might disrupt thyroid function. However, there is no clear evidence of PCB exposure disrupting thyroid hormone (TH) homeostasis in dogs and cats. ... -
Effects of the organochlorine p,p’-DDT on MCF-7 cells: investigating metabolic and immune modulatory transcriptomic changes
Thompson, Lesa A.; Ikenaka, Yoshinori; Darwish, Wageh Sobhy; Nakayama, Shouta M.M.; Mizukawa, Hazuki (Elsevier, 2019)The organochlorine pesticide dichloro-diphenyl-trichloroethane (DDT) is persistent in the environment and leadsto adverse human health effects. High levels in breast milk pose a threat to both breast tissue and nursing ... -
The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not
Kawai, Yusuke K.; Ikenaka, Yoshinori; Ishizuka, Mayumi; Kubota, Akira (PLoS, 2018)UDP-glycosyltransferase (UGT) catalyzes the transfer of glycosyl groups (e.g., glucuronic acid) to exogenous or endogenous chemicals and plays an important role in conjugation reactions. In vertebrates, UGT genes are ... -
Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana
Bortey-Sam, Nasta; Ikenaka, Yoshinori; Akoto, Osei; Nakayama, Shouta M.M.; Marfo, Jemima (Elsevier, 2016)Previous studies of polycyclic aromatic hydrocarbons (PAHs) in particulate matter, soils and livers of wild rats indicated that the city centre of Kumasi, Ghana has been severely polluted with high cancer potency. Cattle ... -
Exposures of children to neonicotinoids in pine wilt disease control areas
Ikenaka, Yoshinori; Miyabara, Yuichi; Ichise, Takahiro; Nakayama, Shouta; Collins, Nimako (Wiley, 2019)Neonicotinoid insecticides that have been on the market since 1992 have been used globally including in Japan. Because they are sprayed over forests and agricultural areas, inadvertent toxicity in nontarget insects (especially ... -
Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells
Hirano, Tetsushi; Ikenaka, Yoshinori; Minagawa, Satsuki; Furusawa, Yukihiro; Yunoki, Tatsuya (Elsevier, 2019)Neonicotinoids are one of most widely used pesticides targeting nicotinic acetylcholine receptors (nAChRs) of insects. Recent epidemiological evidence revealed increasing amounts of neonicotinoids detected in human samples, ... -
How toxic is a non-toxic nanomaterial: behaviour as an indicator of effect in Danio rerio exposed to nanogold
Botha, Tarryn L.; Brand, Sarel J.; Ikenaka, Yoshinori; Wepener, Victor; Nakayama, Shouta M.M. (Elsevier, 2019)Gold nanoparticles are used as drug delivery vectors based on the assumption that they have low toxicity. Literature has, however, produced conflicting results over the last few years. As such, this study aimed to investigate ... -
Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats (Rattus rattus) in Tokyo by in situ liver perfusion
Takeda, Kazuki; Ikenaka, Yoshinori; Tanaka, Kazuyuki; Nakayama, Shouta M.M.; Tanikawa, Tsutomu (Elsevier, 2018)Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition ... -
Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats (Rattus rattus) in Tokyo by in situ liver perfusion
Takeda, Kazuki; Ikenaka, Yoshinori; Tanaka, Kazuyuki D.; Nakayama, Shouta M.M.; Tanikawa, Tsutomu (Elsevier, 2018)Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition ...