Browsing Faculty of Natural and Agricultural Sciences by Author "10059768 - Breytenbach, Jaco Cornelius"
Now showing items 1-8 of 8
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1-Bromo-2-(10 β-dihydroartemisinoxy)-ethane
Lombard, Marli C.; N'Da, David D.; Breytenbach, Jaco C.; Fernandes, Manuel A. (IUCr, 2010)The title compound, C17H27BrO5, DEB, is a derivative of artemisinin which is used in malaria therapy. The OR-group at C12 is cis to the CH3-group at C11 and axially oriented on ring D which has a chair conformation. The ... -
In-vitro transdermal penetration of cytarabine and its N4-alkylamide derivatives
Legoabe, Lesetja J.; Breytenbach, Jaco C.; N'Da, David D.; Breytenbach, J. Wilma (Wiley, 2010)Objectives The aim of this study was to synthesise and determine the transdermal penetration of cytarabine alkylamide derivatives and assess the correlation of flux with physicochemical properties. Methods The alkylamide ... -
Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin
Steyn, Minette; N'Da, David D.; Breytenbach, Jaco C.; Breytenbach, Wilma J.; Smith, Peter J.; Meredith, Sandra (Wiley, 2011)Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ... -
Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin
Steyn, Minette; N’Da, David D.; Breytenbach, Jaco C.; Breytenbach, Wilma J.; Smith, Peter J. (Wiley, 2011)Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ... -
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
Van Heerden, Lezanne; Cloete, Theunis T.; Breytenbach, J. Wilma; Breytenbach, Jaco C.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2012)Series of bisquinolines 4e15 and bispyrrolo[1,2a]quinoxalines 16e20 containing various polyamine linkers were synthesized. The aqueous solubility and distribution coefficient were experimentally determined. The compounds ... -
Synthesis and in vitro human skin penetration of oligo- and polymeric ethylene glycol carbonates of zidovudine and stavudine
N'Da, David D.; Breytenbach, Jaco C.; Breytenbach, J. Wilhelmina (Thieme, 2010)In continuation of studies focusing on the transdermal delivery of antiretroviral (ARV) drugs, the skin permeation ability of synthesized homologous series of both oligomeric and polymeric ethylene glycol (PEG) carbonates ... -
Synthesis and in vitro transdermal penetration of methoxypoly(ethylene glycol) carbonate derivatives of stavudine (3TC)
N'Da, David D.; Breytenbach, Jaco C.; Legoabe, Lesetja J.; Breytenbach, J. Wilma (Bentham Science, 2009)The objective of this study was to synthesize derivatives of the anti-HIV drug stavudine (d4T) with more favourable physicochemical properties for transdermal delivery in an effort to increase transdermal penetration of ... -
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
Cloete, Theunis T.; Breytenbach, J. Wilma; Breytenbach, Jaco C.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2012)In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ...