Browsing Faculty of Natural and Agricultural Sciences by Author "10206280 - Terre'Blanche, Gisella"
Now showing items 1-7 of 7
-
8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity
Carrageta, David F.; Van der Walt, Mietha M.; Terre'Blanche, Gisella; Dias, Tânia R.; Jarak, Ivana (Elsevier, 2018)Caffeine is one of the most worldwide consumed methylxanthines. It is well-known for its thermogenic and cell metabolism modulating effects. Based on methylxanthines' chemical structure, 8-(3-phenylpropyl)-1,3,7-triethylxanthine ... -
C2-substituted quinazolinone derivatives exhibit A1 and/or A2A adenosine receptor affinities in the low micromolar range
Pieterse, Lianie; Van der Walt, Mietha M.; Terre'Blanche, Gisella (Elsevier, 2020)Antagonists of the adenosine receptors (A1 and A2A subtypes) are widely researched as potential drug candidates for their role in Parkinson’s disease-related cognitive deficits (A1 subtype), motor dysfunction (A2A subtype) ... -
Die identifisering van fenielbottersuur aromatiese metaboliete in die urien van die blou-aap
Van der Linde, Wilhelmina J.; Mienie, Lodewyk J.; Bergh, Jacobus J.; Van der Walt, Mietha M.; Terre'Blanche, Gisella (Suid-Afrikaanse Akademie vir Wetenskap en Kuns, 2018)Phenylbutyrate (PBA) is used as treatment of urea cycle disorders and as an alternative treatment option for adrenoleykodystrophy, has neuroprotective effects and provides protection against oxidative stress. Known ... -
Investigating the potential neuroprotective effects of statins on DNA damage in mouse striatium
Coetsee, T.N.; Pretorius, P.J.; Terre'Blanche, G.; Bergh, J.J. (Elsevier, 2008)We investigated the protective effect of pravastatin, simvastatin and atorvastatin on striatal DNA damage as a potential method to conserve and protect the nigrostriatal neurons. C57Bl/J6 mice were treated with combinations ... -
Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate
Viljoen, Jacques; Bergh, Jacobus J.; Mienie, Lodewyk J.; Terre'Blanche, Gisella; Kotzé, Herculaas F. (Springer, 2012)Valproate administration increases the level of the inhibitory transmitter, glycine, in the urine and plasma of patients and experimental animals. Nonketotic hyperglycinemia (NKH), an autosomal recessive disorder of ... -
The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time
Terre'Blanche, Gisella; Heyer, Nicolette; Bergh, Jacobus J.; Mienie, Lodewyk J.; Harvey, Brian H.; Van der Schyf, Cornelius J. (Springer, 2011)Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in ... -
Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid: a case report
Terre'Blanche, Gisella; Van der Walt, Mietha M.; Bergh, Jacobus J.; Mienie, Lodewyk J. (BioMed Central, 2011)This is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration (VLCFA). ...