Browsing Faculty of Natural and Agricultural Sciences by Author "22713077 - Vorster, Barend Christiaan"
Now showing items 1-14 of 14
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ALG6-CDG in South Africa: genotype-phenotype description of five novel patients
Dercksen, M.; Mienie, L.J.; Vorster, B.C.; Crutchley, A.C.; Honey, E.M. (Springer, 2012)ALG6-CDG (formerly named CDG-Ic) (phenotype OMIM 603147, genotype OMIM 604566), is caused by defective endoplasmic reticulum a-1,3-glucosyltransferase (E.C 2.4.1.267) in the N-glycan assembly pathway (Gr€unewald et al. ... -
Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge
Erasmus, Elardus; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J.; Steffens, Francois E. (Public Library of Science, 2019)Chronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped ... -
A call for global action for rare diseases in Africa
Baynam, Gareth S.; Van der Westhuizen, Francois H.; Vorster, Barend C.; Groft, Stephen; Gassman, Safiyya D. (Springer Nature, 2020)The 11th International Conference on Rare Diseases and Orphan Drugs (ICORD), South Africa, included the Africa-Rare initiative launch and facilitated multi-stakeholder engagement in the challenges facing, and opportunities ... -
Challenges and opportunities for biological mass spectrometry core facilities in the developing world
Bell, Liam; Vorster, Barend C.; Calder, Bridget; Hiller, Reinhard; Klein, Ashwil (The Association of Biomolecular Resource Facilities, 2018)The developing world is seeing rapid growth in the availability of biological mass spectrometry (MS), particularly through core facilities. As proteomics and metabolomics becomes locally feasible for investigators in these ... -
Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project
McHugh, David M.S.; Klopper, Brenda; Vorster, Barend Christiaan; Cameron, Cynthia A.; Abdenur, Jose E. (Springer Nature, 2011)Purpose: To achieve clinical validation of cutoff values for newborn screening by tandem mass spectrometry through a worldwide collaborative effort. Methods: Cumulative percentiles of amino acids and acylcarnitines in ... -
The contribution of the C-824T tyrosine hydroxylase polymorphism to the prevalence of hypertension in a South African cohort: the SABPA study
Van Deventer, Cindy A.; Louw, Roan; Van der Westhuizen, Francois H.; Vorster, Chris B.; Malan, Leoné (Taylor & Francis, 2013)The C-824T single nucleotide polymorphism in the promoter region of the tyrosine hydroxylase gene has been associated with hypertension. It is well documented that African South Africans exhibit a higher prevalence of ... -
Facile immobilization of glucose oxidase onto gold nanostars with enhanced binding affinity and optimal function
Phiri, Masauso Moses; Mulder, Danielle Wingrove; Mason, Shayne; Vorster, Barend Christiaan (Royal Society, 2019)Gold nanoparticles provide a user-friendly and efficient surface for immobilization of enzymes and proteins. In this paper, we present a novel approach for enzyme bioconjugation to gold nanostars (AuNSs). AuNSs were modified ... -
Gold nanostar colorimetric detection of fructosyl valine as a potential future point of care biosensor candidate for glycated haemoglobin detection
Mulder, Danielle Wingrove; Phiri, Masauso Moses; Vorster, Barend Christiaan (MDPI, 2019)Diabetes Mellitus is a growing global concern. The current methods used to detect glycated haemoglobin are precise, however, utilise expensive equipment, reagents and consumables. These are luxuries which rural communities ... -
A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?
Erasmus, Elardus; Mason, Shayne; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J. (Springer, 2019)Introduction Manifestations of fatigue range from chronic fatigue up to a severe syndrome and myalgic encephalomyelitis. Fatigue grossly affects the functional status and quality of life of affected individuals, prompting ... -
Modified HEPES one-pot synthetic strategy for gold nanostars
Mulder, Danielle Wingrove; Phiri, Masauso Moses; Jordaan, Anine; Vorster, Barend Christiaan (RSC, 2019)Gold nanostars are being used more regularly in the biosensing field. Despite their useful attributes, there is still a need to optimize aspects of the synthesis and stability. The seedless, synthetic method comprising ... -
Plasmonic detection of glucose in serum based on biocatalytic shape-altering of gold nanostars
Phiri, Masauso Moses; Mulder, Danielle Wingrove; Vorster, Barend Christiaan (MDPI, 2019)Nanoparticles have been used as signal transducers for optical readouts in biosensors. Optical approaches are cost-e ective with easy readout formats for clinical diagnosis. We present a glucose biosensor based on the ... -
Seedless gold nanostars with seed-like advantages for biosensing applications
Phiri, Masauso Moses; Mulder, Danielle Wingrove; Vorster, Barend Christiaan (The Royal Society, 2019)Gold nanostars (AuNSs) are seen as promising building blocks for biosensors with potential for easy readouts based on naked-eye and ultraviolet–visible spectroscopy detection. We present a seedless synthesis strategy for ... -
Silent ischemia is associated with subclinical atherosclerosis in African males: the sympathetic activity and ambulatory blood pressure in Africans study
Griffiths, Madelein E.; Malan, Leoné; Van Rooyen, Johannes M.; Koekemoer, Gerhard; Vorster, Chris B. (Taylor & Francis, 2012)Silent myocardial ischemia is a predictor of subclinical atherosclerosis driven by increased cardiovascular risk markers, although still unknown in Africans. The aim of this study was to assess if cardiovascular risk markers ... -
Tailor-made gold nanostar colorimetric detection determined by morphology change and used as an indirect approach by using hydrogen peroxide to determine glucose concentration
Mulder, Danielle Wingrove; Phiri, Masauso Moses; Vorster, Barend Christiaan (Elsevier, 2019)Gold nanostars are being utilized more regularly in the field of nanodiagnostics. The modified seedless synthetic method comprised of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) synthesized with the ...