Browsing Faculty of Natural and Agricultural Sciences by Author "Watanabe, Kensuke P."
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Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: in vitro assays in several birds and in vivo assays in chicken
Watanabe, Kensuke P.; Ikenaka, Yoshinori; Kawata, Minami; Nakayama, Shouta M.M.; Ishii, Chihiro (Wiley, 2015)Coumarin-derivative anticoagulant rodenticides used for rodent control are posing a serious risk to wild bird populations. For warfarin, a classic coumarin derivative, chickens have a high median lethal dose (LD50), whereas ... -
Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats
Nishiyama, Yoshihiro; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Watanabe, Kensuke P.; Kawai, Yusuke K. (Japan Soc Vet Sci, 2016)Rat cytochrome P450 (CYP) exhibits inter-strain differences, but their analysis has been scattered across studies under different conditions. To identify these strain differences in CYP more comprehensively, mRNA expression, ...