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Uncovering the metabolic response of abalone (Haliotis midae) to environmental hypoxia through metabolomics
(Springer, 2018)
Introduction
Oxygen is essential for metabolic processes and in the absence thereof alternative metabolic pathways are required for energy production, as seen in marine invertebrates like abalone. Even though hypoxia has ...
The cross-tissue metabolic response of abalone (Haliotis midae) to functional hypoxia
(The Company of Biologists, 2018)
Functional hypoxia is a stress condition caused by the abalone itself as
a result of increased muscle activity, which generally necessitates the
employment of anaerobic metabolism if the activity is sustained for
prolonged ...
Metabolomics reveals the depletion of intracellular metabolites in HepG2 cells after treatment with gold nanoparticles
(Taylor & Francis, 2018)
Studies on the safety of gold nanoparticles (GNPs) are plentiful due to their successful application in drug delivery and treatment of diseases in trials. Cytotoxicity caused by GNPs has been studied on the physiological ...
Miniaturized 1H-NMR method for analyzing limited-quantity samples applied to a mouse model of Leigh disease
(Springer, 2018)
Introduction
The analysis of limited-quantity samples remains a challenge associated with mouse models, especially for multi-platform metabolomics studies. Although inherently insensitive, the highly specific characteristics ...
GC-MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption
(Nature, 2018)
Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways. Moreover, the holistic approach of such studies gives insights into the ...
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS)
(Elsevier, 2019)
We used a comprehensive metabolomics approach to study the altered urinary metabolome of two mitochondrial myopathy, encephalopathy lactic acidosis and stroke like episodes (MELAS) cohorts carrying the m.3243A>G mutation.
The ...
Miniaturized 1H-NMR method for analyzing limited-quantity samples applied to a mouse model of Leigh disease
(Springer, 2018)
Introduction
The analysis of limited-quantity samples remains a challenge associated with mouse models, especially for multi-platform metabolomics studies. Although inherently insensitive, the highly specific characteristics ...
Metabolic characterization of tuberculous meningitis in a South African paediatric population using 1H NMR metabolomics
(Elsevier, 2020)
Objective
To better characterize the cerebrospinal fluid (CSF) metabolic profile of tuberculous meningitis (TBM) cases using a South African paediatric cohort.
Methods
1H NMR metabolomics was used to analyse the CSF ...
A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls
(BioMed Central, 2017)
Background:
Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is
uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a ...
Metabolomics of Ndufs4−/− skeletal muscle: adaptive mechanisms converge at the ubiquinone-cycle
(Elsevier, 2019)
Leigh syndrome is one of the most common childhood-onset neurometabolic disorders resulting from a primary oxidative phosphorylation dysfunction and affecting mostly brain tissues. Ndufs4−/− mice have been widely used to ...