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dc.contributor.authorEbenhan, Thomas
dc.contributor.authorSchoeman, Isabel
dc.contributor.authorGrobler, Anne
dc.contributor.authorZeevaart, Jan Rijn
dc.contributor.authorRossouw, Daniel D.
dc.date.accessioned2016-10-27T06:14:15Z
dc.date.available2016-10-27T06:14:15Z
dc.date.issued2016
dc.identifier.citationEbenhan, T. et al. 2016. Evaluation of a flexible NOTA-RGD kit solution using Gallium-68 from different 68Ge/ 68Ga-generators: pharmacokinetics and biodistribution in nonhuman primates and demonstration of solitary pulmonary nodule imaging in humans. Molecular imaging and biology, 19(3):469-482. [https://doi.org/10.1007/s11307-016-1014-1]en_US
dc.identifier.issn1536-1632
dc.identifier.issn1860-2002 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/19207
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs11307-016-1014-1
dc.identifier.urihttps://doi.org/10.1007/s11307-016-1014-1
dc.description.abstractPurpose: Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating Ga-68 from different generators was developed for NOTA-RGD and evaluated for its versatile use and safety in subsequent in vivo applications. The [68Ga]NOTA-RGD kit was further verified for its expected biodistribution and pharmacokinetics in nonhuman primates and its clinical sensitivity to detect solitary pulmonary nodules (SPN) in cancer patients. Procedures: Single vial kits containing 28–56 nmol of NOTA-cyclo-Arg-Gly-Asp-d-Tyr-Lys (NOTA-RGD) and sodium acetate trihydrate buffer were formulated. Versatility of the NOTARGD radiolabeling performance and adaption to a TiO2- and a SnO2-based generator type, characterization and long-term storage stability of the kits were carried out. The blood clearance and urine recovery kinetics as well as the image-guided biodistribution of [68Ga]NOTA-RGD was studied in a vervet monkey model. [68Ga]NOTA-RGD kits were further tested clinically to target solitary pulmonary nodulesen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectGallium-68en_US
dc.subject[68Ga]en_US
dc.subjectRGDen_US
dc.subjectανβ3-integrinen_US
dc.subjectNota-RGDen_US
dc.subjectAngiogenesisen_US
dc.subjectPET/CT-imagingen_US
dc.subjectPeptide radiolabelingen_US
dc.subjectLung canceren_US
dc.titleEvaluation of a flexible NOTA-RGD kit solution using Gallium-68 from different 68Ge/ 68Ga-generators: pharmacokinetics and biodistribution in nonhuman primates and demonstration of solitary pulmonary nodule imaging in humansen_US
dc.typeArticleen_US
dc.contributor.researchID11008857 - Grobler, Anne Frederica
dc.contributor.researchID16951484 - Zeevaart, Jan Rijn


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