dc.contributor.author | Ebenhan, Thomas | |
dc.contributor.author | Schoeman, Isabel | |
dc.contributor.author | Grobler, Anne | |
dc.contributor.author | Zeevaart, Jan Rijn | |
dc.contributor.author | Rossouw, Daniel D. | |
dc.date.accessioned | 2016-10-27T06:14:15Z | |
dc.date.available | 2016-10-27T06:14:15Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Ebenhan, T. et al. 2016. Evaluation of a flexible NOTA-RGD kit solution using Gallium-68 from different 68Ge/ 68Ga-generators: pharmacokinetics and biodistribution in nonhuman primates and demonstration of solitary pulmonary nodule imaging in humans. Molecular imaging and biology, 19(3):469-482. [https://doi.org/10.1007/s11307-016-1014-1] | en_US |
dc.identifier.issn | 1536-1632 | |
dc.identifier.issn | 1860-2002 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/19207 | |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs11307-016-1014-1 | |
dc.identifier.uri | https://doi.org/10.1007/s11307-016-1014-1 | |
dc.description.abstract | Purpose: Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid
(RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit
radiolabeling procedure accommodating Ga-68 from different generators was developed for
NOTA-RGD and evaluated for its versatile use and safety in subsequent in vivo applications.
The [68Ga]NOTA-RGD kit was further verified for its expected biodistribution and pharmacokinetics
in nonhuman primates and its clinical sensitivity to detect solitary pulmonary nodules
(SPN) in cancer patients.
Procedures: Single vial kits containing 28–56 nmol of NOTA-cyclo-Arg-Gly-Asp-d-Tyr-Lys
(NOTA-RGD) and sodium acetate trihydrate buffer were formulated. Versatility of the NOTARGD
radiolabeling performance and adaption to a TiO2- and a SnO2-based generator type,
characterization and long-term storage stability of the kits were carried out. The blood clearance
and urine recovery kinetics as well as the image-guided biodistribution of [68Ga]NOTA-RGD was
studied in a vervet monkey model. [68Ga]NOTA-RGD kits were further tested clinically to target
solitary pulmonary nodules | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | Gallium-68 | en_US |
dc.subject | [68Ga] | en_US |
dc.subject | RGD | en_US |
dc.subject | ανβ3-integrin | en_US |
dc.subject | Nota-RGD | en_US |
dc.subject | Angiogenesis | en_US |
dc.subject | PET/CT-imaging | en_US |
dc.subject | Peptide radiolabeling | en_US |
dc.subject | Lung cancer | en_US |
dc.title | Evaluation of a flexible NOTA-RGD kit solution using Gallium-68 from different 68Ge/ 68Ga-generators: pharmacokinetics and biodistribution in nonhuman primates and demonstration of solitary pulmonary nodule imaging in humans | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 11008857 - Grobler, Anne Frederica | |
dc.contributor.researchID | 16951484 - Zeevaart, Jan Rijn | |