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dc.contributor.authorGidaro, Maria Concetta
dc.contributor.authorPetzer, Anél
dc.contributor.authorPetzer, Jacobus P.
dc.contributor.authorAstorino, Christian
dc.contributor.authorCarradori, Simone
dc.date.accessioned2016-10-31T09:38:14Z
dc.date.available2016-10-31T09:38:14Z
dc.date.issued2016
dc.identifier.citationGidaro, M.C. et al. 2016. Kaempferol as selective human MAO‑A inhibitor: analytical detection in Calabrian red wines, biological and molecular modeling studies. Journal of agricultural and food chemistry, 64(6):1394-1400. [https://doi.org/10.1021/acs.jafc.5b06043]en_US
dc.identifier.issn0021-8561
dc.identifier.issn1520-5118 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/19241
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.jafc.5b06043
dc.identifier.urihttps://doi.org/10.1021/acs.jafc.5b06043
dc.description.abstractThe purpose of this work was to determine the kaempferol content in three red wines of Calabria, a southern Italian region with a great number of certified food products. Considering that wine cultivar, climate, and soil influence the qualitative and quantitative composition in flavonoids of Vitis vinifera L. berries, the three analyzed samples were taken from the 2013 vintage. Moreover, the Gaglioppo samples, with assigned Controlled Origin Denomination (DOC), were also investigated in the production of years 2008, 2010, and 2011. In addition to the analysis of kaempferol, which is present in higher concentration than in other Italian wines, in vitro assays were performed to evaluate, for the first time, the inhibition of the human monoamine oxidases (hMAO-A and hMAO-B). Molecular recognition studies were also carried out to provide insight into the binding mode of kaempferol and selectivity of inhibition of the hMAO-A isoformen_US
dc.language.isoenen_US
dc.publisherACSen_US
dc.subjectFlavonoidsen_US
dc.subjectRed wineen_US
dc.subjectMonoamine oxidaseen_US
dc.subjectInhibitionen_US
dc.subjectComputational chemistryen_US
dc.titleKaempferol as selective human MAO‑A inhibitor: analytical detection in Calabrian red wines, biological and molecular modeling studiesen_US
dc.typeArticleen_US
dc.contributor.researchID12264954 - Petzer, Anél
dc.contributor.researchID10727388 - Petzer, Jacobus Petrus


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