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dc.contributor.authorMaritz, Melissa
dc.contributor.authorFourie, Catharina M.T.
dc.contributor.authorVan Rooyen, Johannes M.
dc.contributor.authorMoss, Sarah J.
dc.contributor.authorSchutte, Aletta E.
dc.date.accessioned2017-05-15T07:21:17Z
dc.date.available2017-05-15T07:21:17Z
dc.date.issued2016
dc.identifier.citationMaritz, M. et al. 2016. Large artery stiffness is associated with gamma-glutamyltransferase in young, healthy adults: the African-PREDICT study. Journal of the American Society of Hypertension, 10(10):772-781. [http://dx.doi.org/10.1016/j.jash.2016.07.006]
dc.identifier.issn1933-1711
dc.identifier.issn1878-7436 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/23023
dc.identifier.urihttp://dx.doi.org/10.1016/j.jash.2016.07.006
dc.description.abstractIncreased arterial stiffness is linked to cardiovascular disease development, particularly in black populations. Since detrimental health behaviors in young adults may affect arterial stiffness, we determined whether arterial stiffness associates with specific health behaviors, and whether it is more pronounced in young healthy black compared to white adults. We included 373 participants (49% black, 42% men) aged 20–30 years. Mean arterial pressure was higher for blacks than whites (P < .001), but carotid-femoral pulse wave velocity was similar (6.37 vs. 6.36 m/s; P ¼ .89) after adjustment for mean arterial pressure. The black group had higher gamma-glutamyltransferase (GGT) (P < .001), cotinine, reactive oxygen species, interleukin-6, and monocyte-chemoattractant protein-1 (all P .017). Pulse wave velocity related positively and independently to GGT in both groups before and after multiple adjustments (both b ¼ 0.15; P .049). Blacks had an unfavorable vascular profile and higher GGT, possibly indicating a higher vulnerability to cardiovascular disease development, including changes in arterial stiffness. However, this observation needs confirmation
dc.language.isoen
dc.publisherElsevier
dc.subjectEthnicity
dc.subjectHealth behavior
dc.subjectPulse wave velocity
dc.subjectYoung adults
dc.titleLarge artery stiffness is associated with gamma-glutamyltransferase in young, healthy adults: the African-PREDICT study
dc.typeArticle
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia
dc.contributor.researchID22212337 - Maritz, Melissa
dc.contributor.researchID10210407 - Moss, Sarah Johanna
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus


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