Evaluation of the enzyme inhibitory effect of carboxymethylated chitosan / Ian Dewald Oberholzer

dc.contributor.author	Oberholzer, Ian Dewald
dc.date.accessioned	2009-01-30T10:47:59Z
dc.date.available	2009-01-30T10:47:59Z
dc.date.issued	2003
dc.identifier.uri	http://hdl.handle.net/10394/245
dc.description	Thesis (M.Sc. (Pharm.))--North-West University, Potchefstroom Campus, 2004.
dc.description.abstract	Degradation of peroral administered drugs by various enzymes in the gastrointestinal tract has proven to be troublesome for the absorption' and bioavailability of protein and peptide drugs. Mucoadhesive polymers such as poly(acrylates) have proven to inhibit protease enzymes responsible for initiating digestion of peptide drugs. Enzyme inhibitors have unique chemical properties enabling it to interact with enzymes to form complexes with such enzymes prohibiting it from functioning properly. Anionic carboxymethylated chitosan derivatives such as N,N-dicarboxymethyl chitosan and N, O-carboxymethyl chitosan display unique structural similarities to enzyme inhibitors being anionic polymers that may interact with bi-valent cations...
dc.subject	Mucoadhesive polymers	en
dc.subject	Protease enzymes	en
dc.subject	Enzyme inhibitors	en
dc.subject	N,N-dicarboxymethyl chitosan	en
dc.subject	N,O-carboxymethyl chitosan	en
dc.subject	Proteolytic [alpha]-chymotrypsin	en
dc.title	Evaluation of the enzyme inhibitory effect of carboxymethylated chitosan / Ian Dewald Oberholzer	en
dc.type	Thesis	en
dc.description.thesistype	Masters