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Evaluation of the enzyme inhibitory effect of carboxymethylated chitosan / Ian Dewald Oberholzer

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dc.contributor.author Oberholzer, Ian Dewald
dc.date.accessioned 2009-01-30T10:47:59Z
dc.date.available 2009-01-30T10:47:59Z
dc.date.issued 2003
dc.identifier.uri http://hdl.handle.net/10394/245
dc.description Thesis (M.Sc. (Pharm.))--North-West University, Potchefstroom Campus, 2004.
dc.description.abstract Degradation of peroral administered drugs by various enzymes in the gastrointestinal tract has proven to be troublesome for the absorption' and bioavailability of protein and peptide drugs. Mucoadhesive polymers such as poly(acrylates) have proven to inhibit protease enzymes responsible for initiating digestion of peptide drugs. Enzyme inhibitors have unique chemical properties enabling it to interact with enzymes to form complexes with such enzymes prohibiting it from functioning properly. Anionic carboxymethylated chitosan derivatives such as N,N-dicarboxymethyl chitosan and N, O-carboxymethyl chitosan display unique structural similarities to enzyme inhibitors being anionic polymers that may interact with bi-valent cations...
dc.publisher North-West University
dc.subject Mucoadhesive polymers en
dc.subject Protease enzymes en
dc.subject Enzyme inhibitors en
dc.subject N,N-dicarboxymethyl chitosan en
dc.subject N,O-carboxymethyl chitosan en
dc.subject Proteolytic [alpha]-chymotrypsin en
dc.title Evaluation of the enzyme inhibitory effect of carboxymethylated chitosan / Ian Dewald Oberholzer en
dc.type Thesis en
dc.description.thesistype Masters


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  • ETD@PUK [5167]
    This collection contains the original digitized versions of research conducted at the North-West University (Potchefstroom Campus)

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