Show simple item record

dc.contributor.authorOberholzer, Ian Dewald
dc.date.accessioned2009-01-30T10:47:59Z
dc.date.available2009-01-30T10:47:59Z
dc.date.issued2003
dc.identifier.urihttp://hdl.handle.net/10394/245
dc.descriptionThesis (M.Sc. (Pharm.))--North-West University, Potchefstroom Campus, 2004.
dc.description.abstractDegradation of peroral administered drugs by various enzymes in the gastrointestinal tract has proven to be troublesome for the absorption' and bioavailability of protein and peptide drugs. Mucoadhesive polymers such as poly(acrylates) have proven to inhibit protease enzymes responsible for initiating digestion of peptide drugs. Enzyme inhibitors have unique chemical properties enabling it to interact with enzymes to form complexes with such enzymes prohibiting it from functioning properly. Anionic carboxymethylated chitosan derivatives such as N,N-dicarboxymethyl chitosan and N, O-carboxymethyl chitosan display unique structural similarities to enzyme inhibitors being anionic polymers that may interact with bi-valent cations...
dc.publisherNorth-West University
dc.subjectMucoadhesive polymersen
dc.subjectProtease enzymesen
dc.subjectEnzyme inhibitorsen
dc.subjectN,N-dicarboxymethyl chitosanen
dc.subjectN,O-carboxymethyl chitosanen
dc.subjectProteolytic [alpha]-chymotrypsinen
dc.titleEvaluation of the enzyme inhibitory effect of carboxymethylated chitosanen
dc.typeThesisen
dc.description.thesistypeMasters


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • ETD@PUK [6393]
    This collection contains the original digitized versions of research conducted at the North-West University (Potchefstroom Campus)

Show simple item record