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dc.contributor.authorMason, Shayne
dc.contributor.authorReinecke, Carolus J.
dc.contributor.authorSolomons, Regan
dc.contributor.authorWevers, Ron
dc.contributor.authorEngelke, Udo F.H.
dc.date.accessioned2017-06-13T06:11:47Z
dc.date.available2017-06-13T06:11:47Z
dc.date.issued2017
dc.identifier.citationMason, S. et al. 2017. 1H NMR spectral identification of medication in cerebrospinal fluid of pediatric meningitis. Journal of pharmaceutical and biomedical analysis, 143:56-61. [https://doi.org/10.1016/j.jpba.2017.04.054]en_US
dc.identifier.issn0731-7085
dc.identifier.issn1873-264X (Online)
dc.identifier.urihttp://hdl.handle.net/10394/24973
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2017.04.054
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0731708517306428
dc.description.abstractExploratory metabolomics studies of cerebrospinal fluid (CSF), using proton nuclear magnetic resonance (1H NMR) spectroscopy, hold major potential application in neurodiagnostics. Such studies, however, rely upon established databases of known metabolites. Here we address the ‘unknowns’ in the 1H NMR spectra of CSF from treated pediatric meningitis cases. Through knowledge of the clinical information given by the pediatrician and analytical application of 1H NMR spectroscopy on pure reference compounds of the medication used, we identified four of the previously unknown compounds in the 1H NMR CSF spectra - the drugs pyrazinamide, isoniazid, acyclovir, and sulfamethoxazole. We report on the one- and two-dimensional 1H NMR spectral data and chemical information of these four compounds. By expanding our knowledge of 1H NMR CSF spectra from treated meningitis cases, we are able to bring 1H NMR closer to the forefront of neurodiagnosticsen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectProton nuclear magnetic resonance (1H NMR)en_US
dc.subjectCerebrospinal fluid (CSF)en_US
dc.subjectPyrazinamideen_US
dc.subjectIsoniaziden_US
dc.subjectAcycloviren_US
dc.subjectSulfamethoxazoleen_US
dc.title1H NMR spectral identification of medication in cerebrospinal fluid of pediatric meningitisen_US
dc.typeArticleen_US
dc.contributor.researchID21487855 - Mason, Shayne William
dc.contributor.researchID10055037 - Reinecke, Carolus Johannes


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