Browsing Electronic Theses and Dissertations (ETDs) by Subject "Clozapine"
Now showing items 1-4 of 4
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Behavioural, neurochemical, inflammatory and mitichondrial markers following social isolation rearing in rats before and after selected deug intervention
(North-West University, 2012)Purpose: Schizophrenia is a progressive degenerative illness that has been causally linked to mitochondrial dysfunction, oxidative stress and a pro-inflammatory state. Social isolation rearing (SIR) in rats models the ... -
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ... -
Clozapine usage in a public sector psychiatric hospital in the Nelson Mandela Metropole
(2013)About 30.00% of schizophrenic patients fail to respond to conventional antipsychotics. Clozapine shows superior efficacy, for both the positive and negative symptoms of schizophrenia, over conventional antipsychotics. The ... -
Oxidative status in rats exposed to social isolation rearing : behavioral pharmacology studies and relevance for schizophrenia
(North-West University, 2009)PURPOSE: Psychotic (positive) symptoms are the most distinctive feature of schizophrenia, although negative symptoms such as emotional flattening, social withdrawal and cognitive disturbances are the most treatment resistant ...