Browsing Electronic Theses and Dissertations (ETDs) by Subject "Biotransformation"
Now showing items 1-8 of 8
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An analytical method to investigate the estrogen metabolism in women taking combined oral contraceptives
(North-West University, 2018)The human body is exposed to numerous (endogenous and exogenous) toxins daily. The body has a protective mechanism to help detoxify certain toxins, through biotransformation processes. However, when exposure exceeds the ... -
Effect of oral contraception on biotransformation, oxidative stress and oxidative damage
(North-West University (South Africa), Potchefstroom Campus, 2015)The first hormonal oral contraceptive was released in 1960, giving women a more efficient way of controlling pregnancy and family planning. A combined oral contraceptive (COC) consists of an estrogen and a progestin compound. ... -
The effect of sulforaphane on oxidative stress and biotransformation in HepaRG cells
(North-West University, 2013)Sulforaphane is an isothiocyanate found in high concentrations in cruciferous vegetables like broccoli. Sulforaphane has received much attention due to the evidence that it inhibits phase I carcinogen-bioactivating enzymes ... -
Establishing three-dimensional cell culture models to measure biotransformation and toxicity
(North-West University, Potchefstroom Campus, 2018)A great proportion of new chemical entities will be terminated from the clinical drug development pipeline as a result of deficiencies in drug absorption, distribution, biotransformation and elimination as well as potential ... -
Investigation of the bi-substrate kinetics of a recombinant human glycine N-acyltransferase with a known non-synonymous single nucleotide polymorphism (N156S)
(North-West University (South Africa), Potchefstroom Campus, 2015)Biotransformation is fast becoming a buzzword of our time. This is due to the ever increasing exposure of humans to xenobiotic substances. The detoxification of these xenobiotics occur via various detoxifying mechanisms ... -
Phase 2 biotransformation : the targeted profiling of glycine amino acid conjugation
(North-West University (South Africa), Potchefstroom Campus, 2015)The hepatic biotransformation system plays an important role in drug metabolism and toxicity and has been studied quite extensively. The importance of the very first biotransformation reaction discovered, namely phase 2 ... -
Phase I and II biotransformation in patients with chronic fatigue
(North-West University (South Africa), 2020)This thesis, titled: ‘Phase I and II biotransformation in patients with chronic fatigue’, forms part of the research and development programme of the Centre for Human Metabolomics at the NWU. There is no consensus definition ... -
The recombinant expression and enzymatic charaterisation of human ACSM2 ligase.
(North-West University (South Africa), 2023-10)Glycine conjugation is a highly conserved Phase 2 biotransformation reaction for xenobiotic carboxylic acids such as benzoate, salicylate, and medium-chain fatty acids. The glycine conjugation pathway can be saturated by ...