Browsing Health Sciences by Title
Now showing items 1011-1030 of 2060
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The impact of PheroidTM technology on the bioavailability and efficacy of anti-tuberculosis drugs in an animal model
(North-West University, 2009)Tuberculosis (TB) is a worldwide pandemic with vast challenges in the fight against the disease. Challenges include the long and tedious treatment regimens and chemotherapy with adverse side effects. One approach in ... -
Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir
(2014)Patients on anti-retroviral (ARV) drug treatment are sometimes simultaneously taking other prescribed drugs and/or over-the-counter drugs and/or herbal remedies. Pharmacokinetic drug-drug or herb-drug interactions can occur ... -
The impact of training on productivity in mass food production
(North-West University, 2004)The motivation for this study was to increase the knowledge of foodservice personnel in mass food production in the foodservice area in which they work and by doing so, increasing their productivity. Training is often used ... -
The impact of workplace relationships on nurse-reported quality of care and patient safety in the North West Province
(North-West University (South-Africa), 2023)Aim and objectives: This study aims to investigate the impact of workplace relationships on nurse-reported quality of care and patient safety. Background: There is a direct link between workplace relationships between ... -
Implementation of hazard analysis and critical control point (HACCP) system in a food service unit serving immuno-suppressed patient diets
(North-West University, 2006)Main aim: To supply recommendations to implement a Hazard Analysis of Critical Control Points (HACCP) system in a hospital food service unit serving low bacterial diets in order to prevent or decrease the infection rates ... -
The implementation of the delivery gap principle to develop an effective transdermal delivery system for caffeine
(2013)Caffeine is frequently used in cosmetics due to its well-characterised skin permeation properties and is widely incorporated in cosmetic-related products intended for skin (Samah & Heard, 2013:631). Despite its polar ... -
The implementation of virtual teams : a theoretical framework
(North-West University, 2003)The impact of globalisation and advanced information technology on service and knowledge-based industries in South Africa contributes to these workplaces becoming increasingly virtual. Virtual teams can be seen as a mechanism ... -
Improvement of the pharmaceutical availability and membrane permeability of furosemide by formulation design
(North-West University (South-Africa), 2021)Furosemide is a well-known loop diuretic having weak acidic chemical properties. Furosemide belongs to the Biopharmaceutical Classification System (BCS) class IV because it has poor aqueous solubility and poor membrane ... -
In silico screening, synthesis and in vitro determination of the biological activities of D-amino acid oxidase inhibitors
(North-West University (South-Africa), 2022)Schizophrenia is a mental disorder with many clinical and therapeutic challenges. Current therapy is based on outdated pathological theories while most antipschycotic drugs have a significant side effect profile. New ... -
In vitro and in silico antimicrobial evaluation of N- methyl-2-phenylmaleimides
(North-West University (South-Africa), 2023)Due to COVID-19, many other pandemics have been overlooked in the past few years. Antimicrobial resistance (AMR) is a pandemic that have killed more people than Human Immunodeficiency Virus (HIV) and malaria in 2019 and ... -
The in vitro and in vivo pharmacokinetic parameters of polylactic–co–glycolic acid nanoparticles encapsulating anti–tuberculosis drugs
(North-West University, 2012)Tuberculosis (TB) is an infectious, deadly disease, caused by Mycobacterium tuberculosis (M.tb). In 2010, there were 8,8 million incident cases of TB globally. South Africa currently has the third highest TB incident ... -
In vitro antimalarial efficacy enhancement of selected antibiotics with PheroidTM technology
(North-West University, 2010)The Plasmodium falciparum parasite, carried by Anopheles mosquitoes, is currently a global problem due to the rising incidence of resistance of the parasite to available antimalaria drugs. Resistance and difficult treatment ... -
In vitro biocompatibility of transferosomes, ethosomes and transethosomes
(North-West University (South-Africa), 2019)Lipid nanocarriers (LN) for transdermal drug delivery, have gained more interest in recent years, due to their rapid penetration into the skin. Liposomes were investigated in the past with the goal of transdermal drug ... -
In vitro cytotoxicity of Siphonochilus aethiopicus in combination with selected fillers for tableting
(North-West University, 2018)The use of herbal medicines is currently experiencing a revival of sorts. However, this resurgence in popularity is casting a much needed light on safety issues relevant to the use thereof, since many herbal products remain ... -
Die in vitro effek van osoon op die marmottragea
(North-West University, 2003)Ozone is a natural occurring allotrope of oxygen with a strong oxidizing potential and a variety of potential uses, including its antimicrobial and deodorising properties. The increased use of ozone led to questions ... -
In vitro efficacy of cations incorporated in Absorbatox® for wound healing
(North-West University (South-Africa), 2020)Wound healing can be described as a cascade of cells activated to restore tissue integrity, in order to regain the body’s natural function. Wound care plays a pivotal role in achieving therapeutic outcomes in wounds to ... -
An in vitro evaluation of the antibacterial and anticancer properties of the antimicrobial peptide nisin Z
(North-West University (South Africa), Potchefstroom Campus, 2018)The rise in antibiotic resistance and the lack of the development of new antibiotics poses a considerable threat to human health. This is especially of concern in individuals who are immune-compromised (due to immunosuppressive ... -
In vitro evaluation of the cytotoxic, antibacterial and antioxidant properties of selected chitosan derivatives and melittin
(North-West University (South Africa) , Potchefstroom Campus, 2015)New excipients to improve the oral absorption of drugs are developing significantly. Polymers are used to enhance drug absorption through the gastrointestinal tract. Chitosan is a biocompatible polymer that is capable of ... -
In vitro evaluation of the efficacy of selected medicinal plant extracts against multidrug resistant cancer cells
(North-West University (South-Africa). Potchefstroom Campus, 2019)Cancer is ranked as one of the leading causes of death globally, and a significant number of these diagnosed malignancies are found in lung tissue. Small cell lung cancer (SCLC) is a high grade neuroendocrine cancer, which ... -
In vitro evaluation of the enzyme inhibition and membrane permeation properties of benzophenones extracted from honeybush
(North-West University (South Africa) , Potchefstroom Campus, 2016)Tea prepared from the honeybush (Cyclopia spp.) plant has become a popular beverage and has been shown to possess medicinal properties. Honeybush plants contain phytochemicals that can contribute to the prevention of certain ...