Browsing Health Sciences by Author "Petzer, A"
Now showing items 1-3 of 3
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An investigation of indanone derivatives as inhibitors of monoamine oxidase
Aucamp, Elani (North-West University (South Africa), Potchefstroom Campus, 2018)MAO-A and MAO-B are two isoforms of mitochondrial monoamine oxidase (MAO) that are responsible for the deamination of various monoamine substrates. For example tyramine and dopamine are metabolised by both MAO isoforms. ... -
Monoamine oxidase inhibition properties of quinolinone analogues
Meiring, Letitia (North-West University (South Africa), Potchefstroom Campus, 2016)Parkinson's disease (PD) is an age-related neurodegenerative disorder characterised by selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of the brain. This leads to the loss of dopamine ... -
The synthesis and evaluation of dual inhibitors of monoamine oxidase and catechol-O-methyltransferase
Engelbrecht, Idalet (North-West University (South Africa), Potchefstroom Campus, 2018)Parkinson’s disease is the second most prevalent neurodegenerative disorder after Alzheimer’s disease. Parkinson’s disease is a debilitating, incurable, bradykinetic disorder which seriously inhibits a patient’s quality ...