Browsing Health Sciences by Subject "Flinders sensitive line rat"
Now showing items 1-5 of 5
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Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Chronic effects of pre-adolescent pharmacological and non-pharmacological interventions on depressive-like behaviour in rats
(North-West University, 2018)Similar to adults, major depressive disorder (MDD) also affects children and adolescents, with comparable treatment outcomes. However, only two antidepressants, namely the serotonin reuptake inhibitors fluoxetine and ... -
Comparative study of N-acetyl cysteine and an experimental xanthone compound on behavioral, immune-inflammatory and redox biomarkers of depression in the Flinders sensitive line rat
(North-West University (South-Africa). Potchefstroom Campus, 2016)The focus of determining the underlying pathophysiological pathways of major depressive disorder (MDD) has shifted from identifying one single hypothesis to the incorporation of various aspects of the disease. Increasing ... -
Long-lasting bio-behavioural effects of early-life sildenafil administration in stress-sensitive versus healthy control rats
(North-West University (South-Africa). Potchefstroom Campus, 2019)Major depressive disorder (MDD) in children and adolescents is prevalent, serious and of great concern globally. Yet, only two selective serotonin reuptake inhibitors (SSRIs) are approved for the treatment of juvenile MDD, ... -
Regional neurochemical characterization of the flinders sensitive line rat with regard to glutamate-nitric oxide and cGMP signalling pathways
(North-West University, 2008)The serious nature of MDD has intensified the need to identify and elucidate new neurobiological targets for antidepressant drug action. Depression presents with evidence for degenerative pathology that relates to disturbances ...