Browsing Health Sciences by Subject "Serotonin"
Now showing items 1-6 of 6
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Development and validation of an animal model of treatment resistant depression
(North-West University (South Africa) , Potchefstroom Campus, 2017)The current investigation focused on the development and validation of an animal model of treatment resistant depression (TRD). In addition, an in-depth review of biomarkers of depression was included which aimed to identify ... -
Dopaminergic and serotonergic modulation of reward appraisal in the zebrafish (Danio rerio)
(North-West University (South-Africa), 2020)Obsessive-compulsive disorder (OCD)1 is a chronic and debilitating neuropsychiatric condition affecting 1 – 3% of the world population. The condition is characterized by two main symptom cohorts namely recurrent, distressing ... -
The effect of early–life exposure of rats to venlafaxine on behaviour and neurological markers of antidepressant action in adulthood
(2014)Major depression is a serious mood disorder affecting more than 120 million people worldwide, irrespective of their race or socio-economic status. This psychiatric disorder is predicted to become the second leading cause ... -
An exploration into the bio-behavioural characteristics of the Ndufs4 (knockout) mice : a novel preclinical perspective on psychiatric conditions
(North-West University (South-Africa), 2023)The brain and its associated disorders as a field of study are extremely complex, even more so when research strives to create models that mimic human psychiatric conditions. Given that psychiatric illnesses are associated ... -
An investigation into the effects of Sceletium tortuosum in a methamphetamine addiction model in Sprague Dawley rats
(North-West University (South-Africa), 2021)Background: Methamphetamine (MA), globally known as “crystal meth”, is a highly addictive psychostimulant, which can be easily synthesized by using over the counter medicine and common household items. It induces intense ... -
Tryptophan metabolism in the deer mouse and its response to serotonergic intervention
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 is a debilitating neuropsychiatric condition that notably infringes on an individual’s quality of life. The condition is characterised by two primary symptoms, namely obsessions (intrusive ...