Browsing Health Sciences by Subject "Artemisone"
Now showing items 1-6 of 6
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Anticancer activities of oxidant-redox drug combinations in lipid excipients
(North-West University, 2018)Genetic alterations in the redox status of cancer cells promotes a continuous and elevated production of reactive oxygen species (ROS), associated in the initiation and progression of tumours. The body's potent antioxidant ... -
The effect of Pheroid® technology on the bioavailability of artemisone in primates
(2014)Malaria is one the world’s most devastating diseases. Several classes of drugs are used to treat malaria. Artemisinin combination therapy is the first line treatment of uncomplicated malaria. The artemisinin derivative, ... -
Natural oil nano-emulsion dispersions for the topical delivery of clofazimine, artemisone and decoquinate
(North-West University, Potchefstroom Campus, 2018)Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb) (Godreuil et al., 2007:1), manifests as an extra-pulmonary disease in 3.7 to 8.4% of cases, whereas cutaneous tuberculosis (CTB), which is uncommon, ... -
Novel artemisinin derivatives with PheroidTM technology for malaria treatment
(North-West University, 2009)Artemisinins are known for their low aqueous solubility and resultant poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate, to low bibavailability. Enzymatic ... -
Synthesis and biological evaluation of novel artemisone derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2015)Despite intensive international efforts to eradicate malaria, the disease, continues to inflict an enormous toll on human lives, especially in Africa. An estimated 198 million malaria cases and 584, 000 deaths were reported ... -
Topical delivery of clofazimine, artemisone and decoquinate utilizing vesicles as carrier system
(North-West University (South Africa), Potchefstroom Campus, 2018)Artemisone, clofazimine and decoquinate are part of the MALTBRedox MRC South African University Flagship Projects, which focus on oxidant-redox drug combinations for the treatment of tuberculosis and a few other diseases. ...