Browsing Health Sciences by Subject "Cytotoxicity"
Now showing items 1-10 of 11
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In vitro cytotoxicity of Siphonochilus aethiopicus in combination with selected fillers for tableting
(North-West University, 2018)The use of herbal medicines is currently experiencing a revival of sorts. However, this resurgence in popularity is casting a much needed light on safety issues relevant to the use thereof, since many herbal products remain ... -
In vitro efficacy of cations incorporated in Absorbatox® for wound healing
(North-West University (South-Africa), 2020)Wound healing can be described as a cascade of cells activated to restore tissue integrity, in order to regain the body’s natural function. Wound care plays a pivotal role in achieving therapeutic outcomes in wounds to ... -
In vitro evaluation of the cytotoxic, antibacterial and antioxidant properties of selected chitosan derivatives and melittin
(North-West University (South Africa) , Potchefstroom Campus, 2015)New excipients to improve the oral absorption of drugs are developing significantly. Polymers are used to enhance drug absorption through the gastrointestinal tract. Chitosan is a biocompatible polymer that is capable of ... -
In vitro evaluation of the efficacy of selected medicinal plant extracts against multidrug resistant cancer cells
(North-West University (South-Africa). Potchefstroom Campus, 2019)Cancer is ranked as one of the leading causes of death globally, and a significant number of these diagnosed malignancies are found in lung tissue. Small cell lung cancer (SCLC) is a high grade neuroendocrine cancer, which ... -
Mechanism of in vitro cytotoxicity of antimicrobial peptides in combination with stabilizing excipients
(North-West University, Potchefstroom Campus, 2018)Emerging antibiotic resistance poses a critical public health threat, particularly the alarming increase of resistant bacteria commonly associated with gastrointestinal (GI) infections. Antimicrobial peptides (AMPs) are a ... -
Synthesis and antimalarial activity screening of artemisinin-acridine hybrids
(2013)Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ... -
Synthesis and biological evaluation of novel artemisone derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2015)Despite intensive international efforts to eradicate malaria, the disease, continues to inflict an enormous toll on human lives, especially in Africa. An estimated 198 million malaria cases and 584, 000 deaths were reported ... -
Transdermal delivery of selected statins formulated in apricot kernel oil emulsions
(North-West University (South-Africa). Potchefstroom Campus, 2019)Statins are the leading active pharmaceutical ingredient (API) in the oral treatment of elevated cholesterol levels in the bloodstream. Oral administered statins claim to have gastro-intestinal side-effects, which could ... -
Transdermal delivery of selected statins formulated in grapeseed oil emulsions
(North-West University (South-Africa), 2020)Hypercholesterolemia can be described as high levels of low-density lipoproteins (LDL) that accumulate in the cells of the body including the liver, spleen and the intestines. Cholesterol is eliminated by increasing ... -
The use of apricot oil emulsions for the transdermal delivery of selected statins
(North-West University (South-Africa). Potchefstroom Campus, 2019)Familial hypercholesterolemia can be described as a condition associated with significantly high levels of low-density lipoprotein (LDL) in the plasma, caused by an autosomal-dominant genetic disorder of lipid metabolism. ...