Browsing Health Sciences by Subject "Forced swim test"
Now showing items 1-6 of 6
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Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Comparative study of N-acetyl cysteine and an experimental xanthone compound on behavioral, immune-inflammatory and redox biomarkers of depression in the Flinders sensitive line rat
(North-West University (South-Africa). Potchefstroom Campus, 2016)The focus of determining the underlying pathophysiological pathways of major depressive disorder (MDD) has shifted from identifying one single hypothesis to the incorporation of various aspects of the disease. Increasing ... -
Development and validation of an animal model of treatment-resistant depression with psychotic features
(North-West University (South-Africa), 2021)Major depression (MD) affects up to 17% of the global population. While effective treatments for MD exist, an underlying interaction between genetic propensity and chronic and/or early life adversity may render these drugs ... -
The effect of early–life exposure of rats to venlafaxine on behaviour and neurological markers of antidepressant action in adulthood
(2014)Major depression is a serious mood disorder affecting more than 120 million people worldwide, irrespective of their race or socio-economic status. This psychiatric disorder is predicted to become the second leading cause ... -
Evaluating the antidepressant-like properties of Sceletium tortuosum, alone and as adjunctive treatment
(North-West University (South-Africa), 2020)BACKGROUND: Millions of people worldwide suffer from major depressive disorder (MDD) which can cause physical and emotional suffering for patients and their loved-ones. Unfortunately current treatment fails in approximately ... -
The modulatory effects of sildenafil and the cholinergic system on antidepressant action in a rat model of depression
(North-West University, 2006)Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, is registered for the treatment of male erectile dysfunction (Viagra®) and pulmonary hypertension (Revatio®) in the United States. PDE5 is found in the ...