Browsing Health Sciences by Author "Manley-King, Clarina Ilara"
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The synthesis and evaluation of N-methyl-2-phenylmaleimide analogues as inhibitors of MAO-B
Manley-King, Clarina Ilara (North-West University, 2008)We have recently demonstrated that 1-methyl-3-phenylpyrrole analogues are moderately potent competitive inhibitors of the enzyme monoamine oxidase B (MAO-B). The most potent analogue was 1-methyl-(4-trifluoromethylphenyl) ... -
The synthesis and evaluation of phthalimide analogues as inhibitors of monoamine oxidase B
Manley-King, Clarina Ilara (North-West University, 2011)Parkinson’s disease (PD) is a multifactorial neurodegenerative disease believed to be caused by a number of factors. This has made the successful treatment of the disease very difficult, as the underlying cause of degeneration ...