Browsing Health Sciences by Subject "Social isolation rearing"
Now showing items 1-4 of 4
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Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Development and validation of an animal model of treatment-resistant depression with psychotic features
(North-West University (South-Africa), 2021)Major depression (MD) affects up to 17% of the global population. While effective treatments for MD exist, an underlying interaction between genetic propensity and chronic and/or early life adversity may render these drugs ... -
Effects of chronic methamphetamine exposure during early or late phase development in normal and social isolation reared rats
(North-West University, 2012)Methamphetamine (MA) abuse is a fast growing drug problem, and is the second most widely abused drug world-wide. MA abuse has been linked to the development of symptoms indistinguishable from schizophrenia, referred to as ... -
Evaluation of agomelatine treatment on neuroendocrine and behavioural markers in social isolation reared rats
(North-West University (South Africa) , Potchefstroom Campus, 2016)Anxiety disorders are extremely prevalent and co-morbid in psychiatric disorders with a complex neurobiology and aetiology. Current treatment options are not sufficiently effective and there is therefore a demand for new ...