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Percutaneous delivery of thalidomide and its N-alkyl analogues for treatment of rheumatoid arthritis
(Potchefstroom University for Christian Higher Education, 1998)
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease associated with high levels of tumour necrosis factor-alpha (TNF-a) in synovial fluid and synovial tissue (Saxne et al., 1989). Thalidomide is a proven ...