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Topical delivery of different ketoconazole and acyclovir formulations
(North-West University, 2012)
Acquired immunodeficiency syndrome (AIDS) has shown a rapid increase in incidence over the past 25 years. Many clinical manifestations occur in patients infected with human immunodeficiency virus (HIV) due to compromised ...
Amorphism and polymorphism of azithromycin
(North-West University, 2012)
Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ...
The development of an oral single dose emulgel formulation for Pheroid® technology
(2014)
Dosage forms have been developed over the years for various applications. The dosage form consists of the active drug in combination with pharmaceutical excipients. The pharmaceutical excipients solubilise, suspend, thicken, ...
Stability of amorphous azithromycin in a tablet formulation
(2014)
It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ...
Formulation, in vitro release and transdermal diffusion of selected retinoids
(North-West University, 2010)
Acne is a multifactorial skin disease affecting about 80 % of people aged 11 to 30. Several systemic and topical treatments are used to treat existing lesions, prevent scarring and suppress the development of new lesions. ...
Transdermal diffusion stability and clinical efficacy of cosmetic formulations containing Rosa rubiginosa rosehip seed oil
(North-West University (South Africa) , Potchefstroom Campus, 2016)
This study aimed at investigating cosmeceutical product development from concept to clinical efficacy testing, using Rosa rubiginosa rosehip seed oil, sourced from Southern African soil.
Rosehip seed oil contains various ...
Preparation, stability and in vitro evaluation of liposomes containing amodiaquine
(North-West University, 2010)
Malaria is a curable disease that claims nearly one million lives each year. Problems with the treatment of malaria arise as resistance spreads and new treatment options are becoming less effective. The need for new ...
The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients
(North-West University (South Africa) , Potchefstroom Campus, 2015)
During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ...
Roxithromycin : a solubility and stability study
(North-West University, 2011)
Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds to the 50S subunit of ...
Development of a stability indicating HPLC method for the Pheroid™ delivery system
(North-West University, 2010)
Stability plays an important role in the development of a new drug product. High Performance Liquid Chromatography (HPLC) is considered a stability indicating method of analysis. It is widely used in the pharmaceutical ...