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The synthesis and evaluation of benzosuberone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)
Monoamine oxidase (MAO) is responsible for the catabolism of neurotransmitters such as serotonin and dopamine in the central nervous system and peripheral tissues. MAO inhibitors such as selegiline play a vital part in the ...
Syntheses of sulfanylphthalimide and xanthine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of adenosine receptors
(North-West University, 2013)
Currently L-DOPA is the drug most commonly used for the treatment of Parkinson’s disease (PD). However, the long-term use of L-DOPA is associated with the development of motor fluctuations and dyskinesias. Treatment mainly ...
Syntheses of 8–(phenoxymethyl)caffeine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of the adenosine A2A receptor
(North-West University, 2013)
Background and rationale: Parkinson’s disease (PD) is a progressive, degenerative disorder of the central nervous system and is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The ...
Screening of virtual libraries for monoamine oxidase inhibitors
(2013)
The traditional view of drug design is that a single drug should interact with a single
molecular target. As science progressed, there was an understanding that most drugs
interact with more than one target and that ...
Aminopyrimidine derivatives as adenosine antagonists
(2013)
Aims of this project - The aim of this study was to design and synthesise novel 2-aminopyrimidine derivatives as potential adenosine A1 and A2A receptor antagonists. Background and rationale - Parkinson’s disease is the ...
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(2013)
Parkinson’s disease is the second most common age-related neurodegenerative disease after Alzheimer’s disease. The characteristic pathological feature of Parkinson’s disease is the loss of neurons in the substantia nigra ...
Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase
(2014)
BACKGROUND AND RATIONALE
Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder affecting the central nervous system, primarily, the substantia nigra. It is characterized by loss of dopaminergic ...
An investigation of plant derived compounds as inhibitors of monoamine oxidase
(North-West University (South-Africa). Potchefstroom Campus, 2019)
Computational chemistry, among other things, elucidates possible drug-molecular target interactions when an algorithm is run on a molecular modelling program. Although it is just a projection of reality, it enables researchers ...
The synthesis and evaluation of tetralone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)
Monoamienoksidase (MAO)-inhibeerders word gebruik vir die behandeling van toestande wat veroorsaak word deur verlaagde vlakke van neuro-oordragstowwe soos dopamien, noradrenalien en serotonien. MAO-inhibeerders is aanvanklik ...
Monoamine oxidase inhibition by indanone and benzoquinone analogues
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Parkinson’s disease (PD) is a neurological disorder of which aging is the greatest risk factor. Over the next fifteen years, the number of persons affected by PD worldwide is expected to increase from 4.6 million to 9.3 ...