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Mitochondrial disorders in the South African context : a clinical and biochemical approach
(North-West University (South Africa), 2011)
In the past, patients with suspected mitochondrial disorders (MDs) were identified only phenotypically in South Africa. However, the specific population-related characteristics were unknown and not documented. Up to as ...
A metabolomics approach for characterising tuberculosis
(North-West University, 2012)
In 2001, the WHO declared tuberculosis (TB) a global emergency, as one third of the world's population suffered from latent M. tuberculosis infection. Today, a decade later, millions of people still die worldwide as a ...
The role of the ESX–3 gene cluster and iron on mycobacterial viability
(North-West University, 2013)
According to the World Health Organization (WHO), M. tuberculosis, the causative agent of TB, accounts for approximately 1.7 million deaths annually. Further contributing causes to the worldwide TB incidence, is the ...
An untargeted LC-MS investigation of South African children with respiratory chain deficiencies
(2014)
Mitochondria are the main site of cellular adenosine triphosphate (ATP) generation which is achieved by a series of multi-subunit complexes and electron carriers which together create the oxidative hosphorylation system ...
Characterising tuberculosis treatment success and failure using metabolomics
(North-West University, 2013)
Tuberculosis (TB) is one of the deadliest infectious diseases of our time, with 1.4 million
deaths globally, recorded in 2010 (3800 deaths a day) by the World Health Organization
(WHO). Currently, South Africa ranks third ...
A metabolomics approach investigating the functionality of the ESX-1 gene cluster in mycobacteria
(North-West University, 2015)
Tuberculosis (TB) claims the lives of millions of individuals each year, and is
consequently the world’s second-most deadly infectious disease after acquired
immune deficiency syndrome (AIDS), responsible for 1.4 million ...
Metabolomics of bilharziasis
(North-West University, 2012)
Bilharziasis, a disease that is a major health problem in tropical and subtropical countries, is caused by worms of the genus Schistosoma. The main disease–causing species are S. haematobium, S. mansoni and S. japonicum. ...
Mammalian cell cultures as models for metabolomic studies
(North-West University, 2012)
The use of cultured cells in metabolomic studies is receiving more and more
attention. There are many advantages when using cultured cells in metabolomic
studies, for example cultured cells can easily be manipulated for ...
A metabolomics study of selected perturbations of normal human metabolism
(North-West University, 2010)
Metabolism is an integrated network of biochemical pathways involving a series of enzymecatalysed anabolic or catabolic reactions in cells. Metabolites are chemical compounds that are involved in or are products ...
Urinary metabolomics investigation of Ndufs4 knockout mice
(North-West University (South Africa), 2020)
Mitochondrial diseases (MDs) are the most common inborn errors of metabolism, with an estimated prevalence of approximately 1 in 5 000 live births, and are mainly caused by deficiencies of complex I (CI) of the oxidative ...