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dc.contributor.authorCarradori, Simone
dc.contributor.authorPetzer, Jacques P.
dc.contributor.authorSecci, Daniela
dc.identifier.citationCarradori, S. et al. 2018. MAO inhibitors and their wider applications: a patent review. Expert opinion on therapeutic patents, 28(3):211-226. []en_US
dc.identifier.issn1744-7674 (Online)
dc.description.abstractIntroduction: Monoamine oxidase (MAO) inhibitors, after the initial ‘golden age’, are currently used as third-line antidepressants (selective MAO-A inhibitors) or clinically enrolled as co-adjuvants for neurodegenerative diseases (selective MAO-B inhibitors). However, the research within this field is always increasing due to their pivotal role in modulating synaptic functions and monoamines metabolism. Areas covered: In this paper, MAO inhibitors (2015–2017) are disclosed ordering all the patents according to their chemical scaffold. Structure-activity relationships (SARs) are extrapolated for the most investigated chemotypes (coumarins, pyrazole/oxazepinones, (hetero)arylamides). 108 Compounds are divided into two main groups: newly synthesized molecules and naturally-occurring metabolites. Finally, new therapeutic options are outlined to ensure a more complete view on the potential of these inhibitors. Expert opinion: New proposed MAO inhibitors are endowed with a marked isoform selectivity, with innovative therapeutic potential toward other targets (gliomas, inflammation, muscle dystrophies, migraine, chronic pain, pseudobulbar affect), and with a promising ability to address multi-faceted pathologies such as Alzheimer’s disease. The increasing number of patents is analyzed collecting data from 2002 to 2017en_US
dc.publisherTaylor & Francisen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectMulti-target inhibitorsen_US
dc.subjectMonoamine oxidaseen_US
dc.subjectNatural productsen_US
dc.subjectParkinson’s diseaseen_US
dc.titleMAO inhibitors and their wider applications: a patent reviewen_US
dc.contributor.researchID10727388 - Petzer, Jacobus Petrus

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