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dc.contributor.authorVan der Westhuizen, Francois H.
dc.contributor.authorJanse van Rensburg, Catharina S.
dc.contributor.authorRautenbach, George S.
dc.contributor.authorLoots, Du Toit
dc.contributor.authorHuysamen, Cristal
dc.contributor.authorLouw, Roan
dc.contributor.authorPretorius, Pieter J.
dc.contributor.authorErasmus, Elardus
dc.contributor.authorMarnewick, Jeanine L.
dc.date.accessioned2009-12-17T07:48:39Z
dc.date.available2009-12-17T07:48:39Z
dc.date.issued2008
dc.identifier.citationVan der Westhuizen, F.H. et al. 2008. In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract. Phytotherapy research, 22(3):376-383. [http://dx.doi.org/10.1002/ptr.2330]en
dc.identifier.issn0951-418X
dc.identifier.issn1099-1573 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/2669
dc.identifier.urihttp://dx.doi.org/10.1002/ptr.2330
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/ptr.2330/abstract
dc.description.abstractThe antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. The effect on antioxidant status and protection against induced oxidative stress were also investigated using primary rat hepatocytes. A RR fruit extract containing 45 g/L total ascorbic acid and 65 g/L total polyphenols was used in this study. Dilutions up to 0.08% (v/v) increased significantly the antioxidant status in primary rat hepatocytes. The glutathione redox state was decreased with RR treatment but was increased in Chang liver cells and MT-2 lymphoblast. No cyto- or genotoxicity were observed at levels of up to 5% (v/v) of the fruit extract. In addition, a significant protection against t-BHP induced oxidative stress was observed in primary rat hepatocytes. The Ames test revealed no mutagenic activity using the Salmonella typhimurium strains TA98, TA100 and TA102. A significant antimutagenic effect of the extract was observed against the metabolic activated mutagens 2-acetylaminofluorene and aflatoxin B1 and to a lesser extent against methyl methanesulfonate. It is concluded that these results support the associated health promoting potential of Rosa Roxburghii fruit and in particular against oxidative stress
dc.language.isoenen
dc.publisherWiley
dc.subjectRosa roxburghii
dc.subjectAntioxidants
dc.subjectAntimutagenic
dc.subjectCOMET
dc.subjectCytotoxicity
dc.titleIn vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extracten
dc.typeArticleen
dc.contributor.researchID10066136 - Erasmus, Elardus
dc.contributor.researchID10213503 - Van der Westhuizen, Francois Hendrikus
dc.contributor.researchID10799508 - Loots, Du Toit
dc.contributor.researchID10986707 - Louw, Roan
dc.contributor.researchID10176705 - Pretorius, Petrus Jacobus


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