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dc.contributor.authorSchutte, Rudolph
dc.contributor.authorNawrot, Tim S
dc.contributor.authorRichart, Tom
dc.contributor.authorThijs, Lutgarde
dc.contributor.authorVanderschueren, Dirk
dc.contributor.authorKuznetsova, Tatiana
dc.contributor.authorVan Hecke, Etienne
dc.contributor.authorRoels, Harry A
dc.contributor.authorStaessen, Jan A
dc.identifier.citationSchutte, R., Nawrot, T.S., Richart, T., Thijs, L., Vanderschueren, D., Kuznetsova, T., Van Hecke, E., Roels, H.A. & Staessen, J.A. 2008. Bone resorption and environmental exposure to cadmium in women: a population study. Environmental health perspectives : EHP, 116(6):777�783, June. []en
dc.identifier.issn1552-9924 (Online)
dc.description.abstractBackground: Environmental exposure to cadmium decreases bone density indirectly through hypercalciuria resulting from renal tubular dysfunction. Objective: We sought evidence for a direct osteotoxic effect of cadmium in women. Methods: We randomly recruited 294 women (mean age, 49.2 years) from a Flemish population with environmental cadmium exposure. We measured 24-hr urinary cadmium and blood cadmium as indexes of lifetime and recent exposure, respectively. We assessed the multivariate-adjusted association of exposure with specific markers of bone resorption, urinary hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) , as well as with calcium excretion, various calciotropic hormones, and forearm bone density. Results: In all women, the effect sizes associated with a doubling of lifetime exposure were 8.4% (p = 0.009) for HP, 6.9% (p = 0.10) for LP, 0.77 mmol/day (p = 0.003) for urinary calcium, �0.009 g/cm2 (p = 0.055) for proximal forearm bone density, and �16.8% (p = 0.065) for serum parathyroid hormone. In 144 postmenopausal women, the corresponding effect sizes were �0.01223 g/cm2 (p = 0.008) for distal forearm bone density, 4.7% (p = 0.064) for serum calcitonin, and 10.2% for bone-specific alkaline phosphatase. In all women, the effect sizes associated with a doubling of recent exposure were 7.2% (p = 0.001) for urinary HP, 7.2% (p = 0.021) for urinary LP, �9.0% (p = 0.097) for serum parathyroid hormone, and 5.5% (p = 0.008) for serum calcitonin. Only one woman had renal tubular dysfunction (urinary retinol-binding protein > 338 �g/day). Conclusions: In the absence of renal tubular dysfunction, environmental exposure to cadmium increases bone resorption in women, suggesting a direct osteotoxic effect with increased calciuria and reactive changes in calciotropic hormones.
dc.publisherNational Institute of Environmetal Health Sciences (NIEHS)en
dc.titleBone resorption and environmental exposure to cadmium in women: a population studyen

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