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dc.contributor.authorKorff, Schaun
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorStein, Dan J.
dc.date.accessioned2010-02-25T05:56:16Z
dc.date.available2010-02-25T05:56:16Z
dc.date.issued2008
dc.identifier.citationKorff, S. et al. 2008. Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. Progress in neuro-psychopharmacology & biological psychiatry, 32(2):348-355. [https://doi.org/10.1016/j.pnpbp.2007.08.032]en
dc.identifier.issn0278-5846
dc.identifier.urihttp://hdl.handle.net/10394/2844
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S027858460700320X
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2007.08.032
dc.description.abstractStereotypy is an important manifestation of obsessive compulsive disorder (OCD). OCD involves disturbed serotonin and dopamine pathways, and demonstrates a selective response to serotonin reuptake inhibitors (SRI), with limited to no response to noradrenaline reuptake inhibitors (NRI). Deer mice (Peromyscus maniculatus bairdii) engage in various spontaneous stereotypic behaviours, including somersaulting, jumping and pattern running, and has to date not been explored for possible relevance for OCD. We studied the population diversity of spontaneous stereotypy in these animals, followed by assessing behavioural response to chronic high and low dose SRI (viz. fluoxetine) and NRI (viz. desipramine) treatment (both 10 mg/kg; 20 mg/kg × 21 days). We also studied behavioural responses to the 5-HT2A/C agonist, meta-chlorophenylpiperazine (mCPP) and the D2 agonist, quinpirole (2 mg/kg and 5 mg/kg respectively × 4 days). Deer mice showed a distinct separation into high and low stereotypic behaviour populations, with high and low dose fluoxetine, but not desipramine, significantly reducing stereotypic behaviour in both populations. A significant attenuation of stereotypy was also observed in both groups following quinpirole or mCPP challenge. In its response to drug treatment, spontaneous stereotypic behaviour in deer mice demonstrates predictive validity for OCD. States of spontaneous stereotypy are attenuated by 5-HT2A/C and dopamine D2 receptor agonists
dc.language.isoenen
dc.publisherElsevieren
dc.subjectDeer mouse
dc.subjectDesipramine
dc.subjectFluoxetine
dc.subjectObsessive compulsive disorder
dc.subjectPharmacological validation
dc.subjectStereotypy
dc.titleStereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorderen
dc.typeArticleen
dc.contributor.researchID11083417 - Harvey, Brian Herbert


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