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dc.contributor.authorBurger, Cornel
dc.contributor.authorAucamp, Marique
dc.contributor.authorDu Preez, Jan
dc.contributor.authorHaynes, Richard K.
dc.contributor.authorDu Plessis, Jeanetta
dc.contributor.authorGerber, Minja
dc.date.accessioned2018-08-20T14:07:54Z
dc.date.available2018-08-20T14:07:54Z
dc.date.issued2018
dc.identifier.citationBurger, C. et al. 2018. Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate. Pharmaceutical research, 35: #186. [https://doi.org/10.1007/s11095-018-2471-9]en_US
dc.identifier.issn0724-8741
dc.identifier.issn1573-904X (Online)
dc.identifier.urihttp://hdl.handle.net/10394/30744
dc.identifier.urihttps://link.springer.com/article/10.1007/s11095-018-2471-9
dc.identifier.urihttps://doi.org/10.1007/s11095-018-2471-9
dc.description.abstractPurpose The aim of this study was to formulate nano-emulsions comprising natural oils and the active pharmaceutical ingredients (APIs) clofazimine (CLF), artemisone (ATM) and decoquinate (DQ) in order to determine effectiveness of the nano-emulsions for topical delivery of the APIs. The APIs alone do not possess suitable physicochemical properties for topical drug delivery. Methods Nano-emulsions were formulated with olive and safflower oils encapsulating the APIs. Skin diffusion and tape stripping studies were performed. By using the lactate dehydrogenase (LDH) assay, in vitro toxicity studies were carried out on immortalized human keratinocytes (HaCaT) cell line to determine cytotoxicities due to the APIs and the nano-emulsions incorporating the APIs. Results The nano-emulsions were effective in delivering the APIs within the stratum corneum-epidermis and the epidermis-dermis, were non-cytotoxic towards HaCaT cell lines (p < 0.05) and inhibited Mycobacterium tuberculosis in vitro. Conclusion Natural oil nano-emulsions successfully deliver CLF, ATM and DQ and in principle could be used as supplementary topical treatment of cutaneous tuberculosis (CTB)en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectArtemisoneen_US
dc.subjectClofazimineen_US
dc.subjectCutaneous tuberculosisen_US
dc.subjectDecoquinateen_US
dc.subjectNano-emulsionsen_US
dc.titleFormulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinateen_US
dc.typeArticleen_US
dc.contributor.researchID21661308 - Burger, Cornel
dc.contributor.researchID11927860 - Aucamp, Marique Elizabeth
dc.contributor.researchID10060510 - Du Preez, Jan Lourens
dc.contributor.researchID10065318 - Du Plessis, Jeanetta
dc.contributor.researchID11329025 - Gerber, Minja
dc.contributor.researchID22966390 - Haynes, Richard Kingston


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